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Title: | The elevated expression of calcitonin receptor by cells recruited into the endothelial layer and neo-intima of atherosclerotic plaque. | Austin Authors: | Wookey, Peter J ;Zulli, Anthony;Hare, David L | Affiliation: | Department of Cardiology, University of Melbourne, Austin Health, Austin Campus, Studley Road, Heidelberg, VIC, 3084, Australia | Issue Date: | 29-Apr-2009 | Publication information: | Histochemistry and Cell Biology 2009; 132(2): 181-9 | Abstract: | Calcitonin receptor-immunoreactive (CTR-ir) endothelial and foam cells were identified in atherosclerotic plaque within the abdominal and thoracic aortas of rabbits fed a cholesterol-supplemented diet. Initially, cells within the endothelial layers of nascent atherosclerotic plaque of arteries were also CD34-positive, a marker of precursor cells of the haematopoietic lineage. In a further rabbit model with more advanced cardiovascular disease, CTR-ir cells were located deeper within the plaque as well as within the endothelial layer overlying the neo-intima. Finally, in the third model, in which the 4-week period on the atherogenic diet was followed by a 12-week period of regression on a normal chow diet, during which serum cholesterol levels returned to the normal range, CTR-ir was markedly reduced in the stabilized fibrous cap of plaque. Thus, the expression of CTR is associated with the early cellular events involved in plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing. | Gov't Doc #: | 19404669 | URI: | http://ahro.austin.org.au/austinjspui/handle/1/10809 | DOI: | 10.1007/s00418-009-0600-6 | ORCID: | 0000-0001-9554-6556 | Journal: | Histochemistry and cell biology | PubMed URL: | 19404669 | Type: | Journal Article | Subjects: | Animals Atherosclerosis.metabolism.pathology Diet, Atherogenic Disease Models, Animal Down-Regulation Immunohistochemistry Male Rabbits Receptors, Calcitonin.biosynthesis Tunica Intima.metabolism.pathology Up-Regulation |
Appears in Collections: | Journal articles |
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