Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10809
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWookey, Peter J-
dc.contributor.authorZulli, Anthony-
dc.contributor.authorHare, David L-
dc.date.accessioned2015-05-16T00:22:46Z
dc.date.available2015-05-16T00:22:46Z
dc.date.issued2009-04-29en
dc.identifier.citationHistochemistry and Cell Biology 2009; 132(2): 181-9en
dc.identifier.govdoc19404669en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10809en
dc.description.abstractCalcitonin receptor-immunoreactive (CTR-ir) endothelial and foam cells were identified in atherosclerotic plaque within the abdominal and thoracic aortas of rabbits fed a cholesterol-supplemented diet. Initially, cells within the endothelial layers of nascent atherosclerotic plaque of arteries were also CD34-positive, a marker of precursor cells of the haematopoietic lineage. In a further rabbit model with more advanced cardiovascular disease, CTR-ir cells were located deeper within the plaque as well as within the endothelial layer overlying the neo-intima. Finally, in the third model, in which the 4-week period on the atherogenic diet was followed by a 12-week period of regression on a normal chow diet, during which serum cholesterol levels returned to the normal range, CTR-ir was markedly reduced in the stabilized fibrous cap of plaque. Thus, the expression of CTR is associated with the early cellular events involved in plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAtherosclerosis.metabolism.pathologyen
dc.subject.otherDiet, Atherogenicen
dc.subject.otherDisease Models, Animalen
dc.subject.otherDown-Regulationen
dc.subject.otherImmunohistochemistryen
dc.subject.otherMaleen
dc.subject.otherRabbitsen
dc.subject.otherReceptors, Calcitonin.biosynthesisen
dc.subject.otherTunica Intima.metabolism.pathologyen
dc.subject.otherUp-Regulationen
dc.titleThe elevated expression of calcitonin receptor by cells recruited into the endothelial layer and neo-intima of atherosclerotic plaque.en
dc.typeJournal Articleen
dc.identifier.journaltitleHistochemistry and cell biologyen
dc.identifier.affiliationDepartment of Cardiology, University of Melbourne, Austin Health, Austin Campus, Studley Road, Heidelberg, VIC, 3084, Australiaen
dc.identifier.doi10.1007/s00418-009-0600-6en
dc.description.pages181-9en
dc.identifier.orcid0000-0001-9554-6556-
dc.identifier.pubmedid19404669-
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
Appears in Collections:Journal articles
Files in This Item:
File SizeFormat 
19404669.pdf64.23 kBAdobe PDFView/Open
Show simple item record

Page view(s)

22
checked on Mar 30, 2023

Download(s)

42
checked on Mar 30, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.