Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26365
Title: Exploratory models comparing ethiodized oil-glue and gold fiducials for bladder radiotherapy image-guidance.
Austin Authors: Lim Joon, Daryl ;Berlangieri, Alexandra ;Harris, Benjamin;Tacey, Mark A ;O'Meara, Rachel ;Pitt, Brent;Viotto, Angela ;Brown, Kerryn ;Schneider, Michal;Lawrentschuk, Nathan;Sengupta, Shomik ;Berry, Colleen ;Jenkins, Trish ;Chao, Michael ;Wada, Morikatsu ;Foroudi, Farshad ;Khoo, Vincent
Affiliation: Royal Marsden NHS Foundation Trust, 203 Fulham Rd, Chelsea, London SW3 6JJ, United Kingdom
Olivia Newton-John Cancer Wellness and Research Centre
Monash University, Department of Medical Imaging and Radiation Sciences, Faculty of Medicine, Nursing and Health Sciences, Wellington Rd, Clayton, Victoria 3800, Australia
Radiation Oncology
Issue Date: Jan-2021
metadata.dc.date: 2021-02-06
Publication information: Physics and Imaging in Radiation Oncology 2021; 17: 77-83
Abstract: Image-guidance with fiducials has been shown to improve pelvic radiotherapy outcome. However, bladder fiducials using ethiodized oil (EO) alone can disperse widely, and gold causes Computed Tomography scan (CT) metal artifacts. The study's purpose was to investigate the ability to deliver EO-tissue glue fiducials and compare them to gold for bladder radiotherapy image guidance. A fluid-filled porcine bladder model was used to assess the ability to cystoscopically inject visible EO glue fiducials into the submucosa. We then transferred the bladders into a porcine pelvis for imaging and compared them to gold fiducials using CT, Cone Beam CT (CBCT), and kilovoltage (KV) planar views. A tissue-equivalent phantom was utilized to analyze the CT number Hounsfield Unit (HU) characteristics and artifacts of the glue and gold fiducials. Percentile ranges and normal tissue voxel percentages of the subsequent CT number voxel histogram from a 2 cm sphere surrounding the fiducial was used to characterize the artifact. We successfully delivered all EO glue fiducials into the porcine bladders as discrete fiducials. They were well seen on CT, CBCT, and KV imaging. The glue fiducials had lower CT number values, but less CT number spread of the voxel percentile ranges consistent with the diminished contrast and less artifact than gold. The glue fiducial types had similar CT number characteristics. This study has shown that EO glue fiducials can be delivered with online visualization qualities comparable to gold fiducials without metal-related artifacts.
URI: https://ahro.austin.org.au/austinjspui/handle/1/26365
DOI: 10.1016/j.phro.2021.01.008
PubMed URL: 33898783
Type: Journal Article
Subjects: Bladder cancer
Glue fiducials
Image-guided radiotherapy
Liquid fiducials
Prostate cancer
Radiotherapy
Appears in Collections:Journal articles

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