Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26365
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dc.contributor.authorLim Joon, Daryl-
dc.contributor.authorBerlangieri, Alexandra-
dc.contributor.authorHarris, Benjamin-
dc.contributor.authorTacey, Mark A-
dc.contributor.authorO'Meara, Rachel-
dc.contributor.authorPitt, Brent-
dc.contributor.authorViotto, Angela-
dc.contributor.authorBrown, Kerryn-
dc.contributor.authorSchneider, Michal-
dc.contributor.authorLawrentschuk, Nathan-
dc.contributor.authorSengupta, Shomik-
dc.contributor.authorBerry, Colleen-
dc.contributor.authorJenkins, Trish-
dc.contributor.authorChao, Michael-
dc.contributor.authorWada, Morikatsu-
dc.contributor.authorForoudi, Farshad-
dc.contributor.authorKhoo, Vincent-
dc.date2021-02-06-
dc.date.accessioned2021-05-03T05:19:47Z-
dc.date.available2021-05-03T05:19:47Z-
dc.date.issued2021-01-
dc.identifier.citationPhysics and Imaging in Radiation Oncology 2021; 17: 77-83en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26365-
dc.description.abstractImage-guidance with fiducials has been shown to improve pelvic radiotherapy outcome. However, bladder fiducials using ethiodized oil (EO) alone can disperse widely, and gold causes Computed Tomography scan (CT) metal artifacts. The study's purpose was to investigate the ability to deliver EO-tissue glue fiducials and compare them to gold for bladder radiotherapy image guidance. A fluid-filled porcine bladder model was used to assess the ability to cystoscopically inject visible EO glue fiducials into the submucosa. We then transferred the bladders into a porcine pelvis for imaging and compared them to gold fiducials using CT, Cone Beam CT (CBCT), and kilovoltage (KV) planar views. A tissue-equivalent phantom was utilized to analyze the CT number Hounsfield Unit (HU) characteristics and artifacts of the glue and gold fiducials. Percentile ranges and normal tissue voxel percentages of the subsequent CT number voxel histogram from a 2 cm sphere surrounding the fiducial was used to characterize the artifact. We successfully delivered all EO glue fiducials into the porcine bladders as discrete fiducials. They were well seen on CT, CBCT, and KV imaging. The glue fiducials had lower CT number values, but less CT number spread of the voxel percentile ranges consistent with the diminished contrast and less artifact than gold. The glue fiducial types had similar CT number characteristics. This study has shown that EO glue fiducials can be delivered with online visualization qualities comparable to gold fiducials without metal-related artifacts.en
dc.language.isoeng
dc.subjectBladder canceren
dc.subjectGlue fiducialsen
dc.subjectImage-guided radiotherapyen
dc.subjectLiquid fiducialsen
dc.subjectProstate canceren
dc.subjectRadiotherapyen
dc.titleExploratory models comparing ethiodized oil-glue and gold fiducials for bladder radiotherapy image-guidance.en
dc.typeJournal Articleen
dc.identifier.journaltitlePhysics and Imaging in Radiation Oncologyen
dc.identifier.affiliationRoyal Marsden NHS Foundation Trust, 203 Fulham Rd, Chelsea, London SW3 6JJ, United Kingdomen
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.affiliationMonash University, Department of Medical Imaging and Radiation Sciences, Faculty of Medicine, Nursing and Health Sciences, Wellington Rd, Clayton, Victoria 3800, Australiaen
dc.identifier.affiliationRadiation Oncologyen
dc.identifier.doi10.1016/j.phro.2021.01.008en
dc.type.contentTexten
dc.identifier.pubmedid33898783
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