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Title: Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir.
Austin Authors: Trevillyan, J ;Angus, Peter W ;Shelton, E;Whitlam, J ;Ierino, F;Pavlovic, J ;Gregory, D;Urbancic, K ;Torresi, Joseph ;Testro, Adam G ;Grayson, M Lindsay 
Affiliation: Austin Health
Issue Date: 3-Jun-2013
Publication information: Antimicrobial Agents and Chemotherapy 2013; 57(8): 4058-60
Abstract: In a prospective study of solid-organ transplant recipients (n = 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by >20% in 14/22 (63.6%). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4%). Subtherapeutic ganciclovir levels (≤ 0.6 mg/liter) were common, occurring in 10/22 patients (45.4%); 7 had severely deficient levels (<0.3 mg/liter).
DOI: 10.1128/AAC.00375-13
Journal: Antimicrobial Agents and Chemotherapy
Type: Journal Article
Subjects: Adult
Antiviral Agents.administration & dosage.therapeutic use
Automatic Data Processing
Cytomegalovirus.isolation & purification
Cytomegalovirus Infections.drug therapy
Ganciclovir.administration & dosage.analogs & derivatives.therapeutic use
Glomerular Filtration Rate
Kidney Transplantation
Liver Transplantation
Middle Aged
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Appears in Collections:Journal articles

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