Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11781
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dc.contributor.authorTrevillyan, Jen
dc.contributor.authorAngus, Peter Wen
dc.contributor.authorShelton, Een
dc.contributor.authorWhitlam, Jen
dc.contributor.authorIerino, Fen
dc.contributor.authorPavlovic, Jen
dc.contributor.authorGregory, Den
dc.contributor.authorUrbancic, Ken
dc.contributor.authorTorresi, Josephen
dc.contributor.authorTestro, Adam Gen
dc.contributor.authorGrayson, M Lindsayen
dc.date.accessioned2015-05-16T01:24:32Z
dc.date.available2015-05-16T01:24:32Z
dc.date.issued2013-06-03en
dc.identifier.citationAntimicrobial Agents and Chemotherapy 2013; 57(8): 4058-60en
dc.identifier.govdoc23733466en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11781en
dc.description.abstractIn a prospective study of solid-organ transplant recipients (n = 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by >20% in 14/22 (63.6%). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4%). Subtherapeutic ganciclovir levels (≤ 0.6 mg/liter) were common, occurring in 10/22 patients (45.4%); 7 had severely deficient levels (<0.3 mg/liter).en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAntiviral Agents.administration & dosage.therapeutic useen
dc.subject.otherAutomatic Data Processingen
dc.subject.otherCreatine.urineen
dc.subject.otherCytomegalovirus.isolation & purificationen
dc.subject.otherCytomegalovirus Infections.drug therapyen
dc.subject.otherFemaleen
dc.subject.otherGanciclovir.administration & dosage.analogs & derivatives.therapeutic useen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherHumansen
dc.subject.otherKidney Transplantationen
dc.subject.otherLiver Transplantationen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPredictive Value of Testsen
dc.subject.otherProspective Studiesen
dc.subject.otherReproducibility of Resultsen
dc.titleElectronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir.en
dc.typeJournal Articleen
dc.identifier.journaltitleAntimicrobial agents and chemotherapyen
dc.identifier.affiliationJanine.trevillyan@monash.eduen
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1128/AAC.00375-13en
dc.description.pages4058-60en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23733466en
dc.type.austinJournal Articleen
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