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Title: The effect of sleep deprivation on BOLD activity elicited by a divided attention task.
Austin Authors: Jackson, Melinda L ;Hughes, Matthew E;Croft, Rodney J;Howard, Mark E ;Crewther, David;Kennedy, Gerard A ;Owens, Katherine;Pierce, Robert J;O'Donoghue, Fergal J ;Johnston, Patrick
Affiliation: Institute for Breathing and Sleep, Austin Health, Melbourne, Australia
Issue Date: 1-Jun-2011
Publication information: Brain Imaging and Behavior; 5(2): 97-108
Abstract: Sleep loss, widespread in today's society and associated with a number of clinical conditions, has a detrimental effect on a variety of cognitive domains including attention. This study examined the sequelae of sleep deprivation upon BOLD fMRI activation during divided attention. Twelve healthy males completed two randomized sessions; one after 27 h of sleep deprivation and one after a normal night of sleep. During each session, BOLD fMRI was measured while subjects completed a cross-modal divided attention task (visual and auditory). After normal sleep, increased BOLD activation was observed bilaterally in the superior frontal gyrus and the inferior parietal lobe during divided attention performance. Subjects reported feeling significantly more sleepy in the sleep deprivation session, and there was a trend towards poorer divided attention task performance. Sleep deprivation led to a down regulation of activation in the left superior frontal gyrus, possibly reflecting an attenuation of top-down control mechanisms on the attentional system. These findings have implications for understanding the neural correlates of divided attention and the neurofunctional changes that occur in individuals who are sleep deprived.
Gov't Doc #: 21271311
DOI: 10.1007/s11682-011-9115-6
Journal: Brain imaging and behavior
Type: Journal Article
Subjects: Adult
Brain.blood supply.physiopathology
Frontal Lobe.blood supply
Magnetic Resonance Imaging
Middle Aged
Parietal Lobe.blood supply
Sleep Deprivation.diagnosis.physiopathology.psychology
Appears in Collections:Journal articles

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