Please use this identifier to cite or link to this item:
Title: Amylin in the periphery.
Austin Authors: Wookey, Peter J ;Xuereb, Loredanna;Tikellis, Christos;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Repatriation Campus, Heidelberg West, Victoria, Australia
Issue Date: 24-Mar-2003
Publication information: Thescientificworldjournal 2003; 3(): 163-75
Abstract: Amylin (islet amyloid polypeptide) is a peptide synthesized principally in the beta-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior. As a hormone, amylin acts to modify gastric motility, renal resorption, and has metabolic actions. It is postulated that the principal function of amylin as a hormone is the activation of physiological processes associated with feeding. As a growth factor, amylin acts on bone cells, renal proximal tubular cells, and islet beta-cells. Amylin has important targets in the brain that mediate its actions in the modification of behavior, including thirst and satiety. In man, amylin can form islet amyloid deposits, an event linked to the reduction of b-cell mass and loss of signal-secretion coupling. Recent evidence has defined a new role for monomeric amylin as a growth factor and regulator of beta-cell mass that is postulated to be a key factor in pathophysiological processes that result in overt diabetes.
Gov't Doc #: 12806128
DOI: 10.1100/tsw.2003.17
Journal: TheScientificWorldJournal
Type: Journal Article
Subjects: Amyloid.physiology
Islet Amyloid Polypeptide
Appears in Collections:Journal articles

Files in This Item:
File Description SizeFormat 
12806128.pdf1.43 MBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Apr 12, 2024


checked on Apr 12, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.