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dc.contributor.authorWookey, Peter Jen
dc.contributor.authorXuereb, Loredannaen
dc.contributor.authorTikellis, Christosen
dc.contributor.authorCooper, Mark Een
dc.date.accessioned2015-05-15T22:38:00Z
dc.date.available2015-05-15T22:38:00Z
dc.date.issued2003-03-24en
dc.identifier.citationThescientificworldjournal 2003; 3(): 163-75en
dc.identifier.govdoc12806128en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9512en
dc.description.abstractAmylin (islet amyloid polypeptide) is a peptide synthesized principally in the beta-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior. As a hormone, amylin acts to modify gastric motility, renal resorption, and has metabolic actions. It is postulated that the principal function of amylin as a hormone is the activation of physiological processes associated with feeding. As a growth factor, amylin acts on bone cells, renal proximal tubular cells, and islet beta-cells. Amylin has important targets in the brain that mediate its actions in the modification of behavior, including thirst and satiety. In man, amylin can form islet amyloid deposits, an event linked to the reduction of b-cell mass and loss of signal-secretion coupling. Recent evidence has defined a new role for monomeric amylin as a growth factor and regulator of beta-cell mass that is postulated to be a key factor in pathophysiological processes that result in overt diabetes.en
dc.language.isoenen
dc.subject.otherAmyloid.physiologyen
dc.subject.otherAnimalsen
dc.subject.otherHumansen
dc.subject.otherIslet Amyloid Polypeptideen
dc.titleAmylin in the periphery.en
dc.typeJournal Articleen
dc.identifier.journaltitleTheScientificWorldJournalen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Repatriation Campus, Heidelberg West, Victoria, Australiaen
dc.identifier.doi10.1100/tsw.2003.17en
dc.description.pages163-75en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12806128en
dc.type.austinJournal Articleen
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptMedicine (University of Melbourne)-
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