Association of Obstructive Sleep Apnea with Post-Acute Sequelae of SARS-CoV-2 infection (PASC).

2023-12-31

Quan, Stuart F

Weaver, Matthew D

Czeisler, Mark É

Barger, Laura K

Booker, Lauren A

Howard, Mark E

Jackson, Melinda L

Lane, Rashon I

McDonald, Christine F

Ridgers, Anna

Robbins, Rebecca

Varma, Prerna

Wiley, Joshua F

Rajaratnam, Shantha M W

Czeisler, Charles A

COVID-19

Long COVID

Obstructive Sleep Apnea

PASC

Post-Acute Sequelae of SARS-CoV-2 infection

Journal Article

0000-0002-9474-7679

0000-0003-3578-336X

0000-0003-3100-7347

0000-0001-8547-7331

#PLACEHOLDER_PARENT_METADATA_VALUE#

0000-0001-7262-2632

0000-0003-4976-8101

0000-0002-0612-1466

0000-0001-6481-3391

0000-0003-1360-9387

0000-0003-0288-2505

0000-0001-5408-1625

0000-0002-0271-6702

0000-0001-7527-8558

0000-0002-7408-1849

10.1101/2023.12.30.23300666

Obstructive sleep apnea (OSA) is associated with COVID-19 infection. Fewer investigations have assessed OSA as a possible risk for the development of Post-Acute Sequelae of SARS-CoV-2 infection (PASC). In a general population, is OSA associated with increased odds of PASC-related symptoms and with an overall definition of PASC? Cross-sectional survey of a general population of 24,803 U.S. adults. COVID-19 infection occurred in 10,324 (41.6%) participants. Prevalence rates for a wide variety of persistent (> 3 months post infection) putative PASC-related physical and mental health symptoms ranged from 6.5% (peripheral edema) to 19.6% (nervous/anxious). In logistic regression models adjusted for demographic, anthropometric, comorbid medical and socioeconomic factors, OSA was associated with all putative PASC-related symptoms with the highest adjusted odds ratios (aOR) being fever (2.053) and nervous/anxious (1.939) respectively. Elastic net regression identified the 13 of 37 symptoms most strongly associated with COVID-19 infection. Four definitions of PASC were developed using these symptoms either weighted equally or proportionally by their regression coefficients. In all 4 logistic regression models using these definitions, OSA was associated with PASC (range of aORs: 1.934-2.071); this association was mitigated in those with treated OSA. In the best fitting overall model requiring ≥3 symptoms, PASC prevalence was 21.9%. In a general population sample, OSA is associated with the development of PASC-related symptoms and a global definition of PASC. A PASC definition requiring the presence of 3 or more symptoms may be useful in identifying cases and for future research.

link

MedRxiv : the Preprint Server for Health Sciences 2023-12-31

MedRxiv : the Preprint Server for Health Sciences