Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/29683
Title: Impact of smoking status and chronic obstructive pulmonary disease on pulmonary complications post lung cancer surgery.
Austin Authors: Jeganathan, Vishnu ;Knight, Simon R ;Bricknell, Matthew;Ridgers, Anna;Wong, Raymond ;Brazzale, Danny J ;Ruehland, Warren R ;Rahman, Muhammad Aziz ;Leong, Tracy L ;McDonald, Christine F 
Affiliation: Thoracic Surgery
Respiratory and Sleep Medicine
Institute for Breathing and Sleep
School of Health, Federation University Australia, Berwick, Victoria, Australia
Faculty of Medicine, University of Melbourne, Parkville, Victoria, Australia
Issue Date: 29-Mar-2022
Date: 2022
Publication information: PloS one 2022; 17(3): e0266052
Abstract: Smoking and chronic obstructive pulmonary disease (COPD) are associated with an increased risk of post-operative pulmonary complications (PPCs) following lung cancer resection. It remains unclear whether smoking cessation reduces this risk. Retrospective review of a large, prospectively collected database of over 1000 consecutive resections for lung cancer in a quaternary lung cancer centre over a 23-year period. One thousand and thirteen patients underwent curative-intent lobectomy or pneumonectomy between 1995 and 2018. Three hundred and sixty-two patients (36%) were ex-smokers, 314 (31%) were current smokers and 111 (11%) were never smokers. A pre-operative diagnosis of COPD was present in 57% of current smokers, 57% of ex-smokers and 20% of never smokers. Just over 25% of patients experienced a PPC. PPCs were more frequent in current smokers compared to never smokers (27% vs 17%, p = 0.036), however, no difference was seen between current and ex-smokers (p = 0.412) or between never and ex-smokers (p = 0.113). Those with a diagnosis of COPD, independent of smoking status, had a higher frequency of both PPCs (65% vs 35%, p<0.01) and overall complications (60% vs 40%, p<0.01) as well as a longer length of hospital stay (10 vs 9 days, p<0.01). Smoking and COPD are both associated with a higher rate of PPCs post lung cancer resection. COPD, independent of smoking status, is also associated with an increased overall post-operative complication rate and length of hospital stay. An emphasis on COPD treatment optimisation, rather than smoking cessation in isolation, may help improve post-operative outcomes.
URI: https://ahro.austin.org.au/austinjspui/handle/1/29683
DOI: 10.1371/journal.pone.0266052
ORCID: https://orcid.org/0000-0002-5113-0302
https://orcid.org/0000-0001-9626-7460
0000-0003-0134-9418
0000-0003-1665-7966
0000-0002-1950-1505
0000-0001-6481-3391
Journal: PloS one
PubMed URL: 35349598
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35349598/
Type: Journal Article
Appears in Collections:Journal articles

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