Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJeganathan, Vishnu-
dc.contributor.authorKnight, Simon R-
dc.contributor.authorBricknell, Matthew-
dc.contributor.authorRidgers, Anna-
dc.contributor.authorWong, Raymond-
dc.contributor.authorBrazzale, Danny J-
dc.contributor.authorRuehland, Warren R-
dc.contributor.authorRahman, Muhammad Aziz-
dc.contributor.authorLeong, Tracy L-
dc.contributor.authorMcDonald, Christine F-
dc.identifier.citationPloS one 2022; 17(3): e0266052en_US
dc.description.abstractSmoking and chronic obstructive pulmonary disease (COPD) are associated with an increased risk of post-operative pulmonary complications (PPCs) following lung cancer resection. It remains unclear whether smoking cessation reduces this risk. Retrospective review of a large, prospectively collected database of over 1000 consecutive resections for lung cancer in a quaternary lung cancer centre over a 23-year period. One thousand and thirteen patients underwent curative-intent lobectomy or pneumonectomy between 1995 and 2018. Three hundred and sixty-two patients (36%) were ex-smokers, 314 (31%) were current smokers and 111 (11%) were never smokers. A pre-operative diagnosis of COPD was present in 57% of current smokers, 57% of ex-smokers and 20% of never smokers. Just over 25% of patients experienced a PPC. PPCs were more frequent in current smokers compared to never smokers (27% vs 17%, p = 0.036), however, no difference was seen between current and ex-smokers (p = 0.412) or between never and ex-smokers (p = 0.113). Those with a diagnosis of COPD, independent of smoking status, had a higher frequency of both PPCs (65% vs 35%, p<0.01) and overall complications (60% vs 40%, p<0.01) as well as a longer length of hospital stay (10 vs 9 days, p<0.01). Smoking and COPD are both associated with a higher rate of PPCs post lung cancer resection. COPD, independent of smoking status, is also associated with an increased overall post-operative complication rate and length of hospital stay. An emphasis on COPD treatment optimisation, rather than smoking cessation in isolation, may help improve post-operative outcomes.en_US
dc.titleImpact of smoking status and chronic obstructive pulmonary disease on pulmonary complications post lung cancer surgery.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePloS oneen_US
dc.identifier.affiliationThoracic Surgeryen_US
dc.identifier.affiliationRespiratory and Sleep Medicineen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationSchool of Health, Federation University Australia, Berwick, Victoria, Australiaen_US
dc.identifier.affiliationFaculty of Medicine, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.pubmedid35349598-, Danny J
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en- and Sleep Medicine- for Breathing and Sleep- Surgery- for Breathing and Sleep- and Sleep Medicine- for Breathing and Sleep- for Breathing and Sleep- and Sleep Medicine- Clinical School of Nursing, La Trobe University- and Sleep Medicine- for Breathing and Sleep- for Breathing and Sleep- and Sleep Medicine-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Oct 2, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.