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Title: | Cognitive late effects following allogeneic stem cell transplantation in haematological cancer patients. | Austin Authors: | Hutchinson, Amanda D;Thompson, Elise;Loft, Nicole;Lewis, Ian;Wilson, Carlene J ;Yong, Agnes S M | Affiliation: | Medical School, University of Western Australia, Perth, WA, USA Precision Medicine Theme, SAHMRI, Adelaide, SA, Australia School of Medicine, University of Adelaide, Adelaide, SA, Australia Department of Haematology, Royal Perth Hospital, Perth, WA, Australia Justice & Society, University of South Australia, Adelaide, SA, Australia Department of Haematology, Royal Adelaide Hospital/SA Pathology, Adelaide, SA, Australia Adelaide Oncology & Haematology, North Adelaide, SA, Australia College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia Olivia Newton-John Cancer Wellness and Research Centre School of Psychology and Public Health, La Trobe University, Melbourne, Vic., Australia |
Issue Date: | Sep-2021 | Date: | 2021-03-28 | Publication information: | European Journal of Cancer Care 2021; 30(5): e13448 | Abstract: | The objective of this exploratory study was to determine the presence and correlates of self-reported cognition in a sample of haematological cancer patients who had undergone allogeneic stem cell transplantation (SCT). Haematological cancer patients (n = 30) who had undergone allogeneic SCT between one and five years previously and age-matched control participants (n = 30) completed questionnaires assessing cognition, affect, sleep quality and fatigue and an assessment of premorbid IQ. Patients reported significantly poorer perceived cognitive ability (d = 1.12) and greater perceived cognitive impairment (d = 0.96) than controls. Lower fatigue was significantly associated with greater perceived cognitive ability (r = 0.75 patients and controls) and less perceived cognitive impairment (r = 0.80 patients; r = 0.57 controls). Interestingly, depression was significantly correlated with perceived cognitive ability in the control group only (r = 0.80). Hierarchical multiple regressions showed that fatigue was a significant predictor of perceived cognitive ability in patients, accounting for 56% of the variance. This study established that self-reported cognitive ability and cognitive impairment was significantly poorer in haematological cancer patients than controls. Furthermore, fatigue was significantly associated with perceived cognitive ability in patients. Future research should focus on identifying interventions that target fatigue in allogeneic SCT recipients in order to improve quality of life throughout survivorship. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/27657 | DOI: | 10.1111/ecc.13448 | ORCID: | 0000-0003-3983-8321 | Journal: | European Journal of Cancer Care | PubMed URL: | 33774876 | Type: | Journal Article | Subjects: | allogeneic stem cell transplant cancer-related cognitive impairment cognition fatigue haematological cancer survivorship |
Appears in Collections: | Journal articles |
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