Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/27657
Title: Cognitive late effects following allogeneic stem cell transplantation in haematological cancer patients.
Austin Authors: Hutchinson, Amanda D;Thompson, Elise;Loft, Nicole;Lewis, Ian;Wilson, Carlene J ;Yong, Agnes S M
Affiliation: Medical School, University of Western Australia, Perth, WA, USA
Precision Medicine Theme, SAHMRI, Adelaide, SA, Australia
School of Medicine, University of Adelaide, Adelaide, SA, Australia
Department of Haematology, Royal Perth Hospital, Perth, WA, Australia
Justice & Society, University of South Australia, Adelaide, SA, Australia
Department of Haematology, Royal Adelaide Hospital/SA Pathology, Adelaide, SA, Australia
Adelaide Oncology & Haematology, North Adelaide, SA, Australia
College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia
Olivia Newton-John Cancer Wellness and Research Centre
School of Psychology and Public Health, La Trobe University, Melbourne, Vic., Australia
Issue Date: Sep-2021
Date: 2021-03-28
Publication information: European Journal of Cancer Care 2021; 30(5): e13448
Abstract: The objective of this exploratory study was to determine the presence and correlates of self-reported cognition in a sample of haematological cancer patients who had undergone allogeneic stem cell transplantation (SCT). Haematological cancer patients (n = 30) who had undergone allogeneic SCT between one and five years previously and age-matched control participants (n = 30) completed questionnaires assessing cognition, affect, sleep quality and fatigue and an assessment of premorbid IQ. Patients reported significantly poorer perceived cognitive ability (d = 1.12) and greater perceived cognitive impairment (d = 0.96) than controls. Lower fatigue was significantly associated with greater perceived cognitive ability (r = 0.75 patients and controls) and less perceived cognitive impairment (r = 0.80 patients; r = 0.57 controls). Interestingly, depression was significantly correlated with perceived cognitive ability in the control group only (r = 0.80). Hierarchical multiple regressions showed that fatigue was a significant predictor of perceived cognitive ability in patients, accounting for 56% of the variance. This study established that self-reported cognitive ability and cognitive impairment was significantly poorer in haematological cancer patients than controls. Furthermore, fatigue was significantly associated with perceived cognitive ability in patients. Future research should focus on identifying interventions that target fatigue in allogeneic SCT recipients in order to improve quality of life throughout survivorship.
URI: https://ahro.austin.org.au/austinjspui/handle/1/27657
DOI: 10.1111/ecc.13448
ORCID: 0000-0003-3983-8321
Journal: European Journal of Cancer Care
PubMed URL: 33774876
Type: Journal Article
Subjects: allogeneic stem cell transplant
cancer-related cognitive impairment
cognition
fatigue
haematological cancer
survivorship
Appears in Collections:Journal articles

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