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Title: To biopsy or not to biopsy? Outcomes following stereotactic body radiotherapy (SBRT) for biopsy-confirmed versus radiologically-diagnosed primary lung cancer in a single Australian institution.
Austin Authors: Koh, Tze Lui ;Ong, Wee Loon ;Farrugia, Briana;Leong, Tracy L ;Lapuz, Carminia ;Lim, Adeline 
Affiliation: School of Clinical Medicine, University of Cambridge, Cambridge, UK
Center for Digital Transformation of Health, The University of Melbourne, Melbourne, VIC, Australia
Respiratory and Sleep Medicine
Department of Medicine, University of Melbourne, Melbourne, VIC, Australia
Radiation Oncology
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia
Olivia Newton-John Cancer Wellness and Research Centre
Issue Date: Jun-2022
Date: 2021-06-29
Publication information: Asia-Pacific Journal of Clinical Oncology 2022-06; 18(3): 319-325
Abstract: Obtaining tissue diagnosis for lung cancer can sometimes be difficult and unsafe. We evaluated outcomes of biopsy-confirmed versus radiologically-diagnosed lung cancer treated with stereotactic body radiotherapy (SBRT). A single-institutional retrospective cohort of lung cancer patients treated with SBRT between February 2014 and October 2018. Outcomes of interest were: local failure (LF), distant failure (DF), and overall survival (OS). Probability of LF, DF, and OS were estimated using the Kaplan-Meier method. Differences in outcomes between biopsy-confirmed versus radiologically-diagnosed lung cancer were evaluated using the log-rank test. Sixty-five lung lesions in 61 patients were treated with SBRT. Mean age was 75.6 years. Twenty-seven patients (44.3%) were ECOG 2-3. Thirty-nine patients (64%) were radiologically-diagnosed. There were five cases of LF observed at median of 12.8 months post-SBRT and 12-month LF-free survival was 96% (95% CI, 86-99%), with no differences between groups (p = 0.1). Sixteen patients developed DF, with 12-month DF-free survival of 84% (95% CI, 71-91%), and no difference between groups (p = 0.06). Sixteen deaths were reported at a median of 12.5 months post-SBRT, with 12-month OS of 85% (95% CI, 73-92%), and no differences between study groups (p = 0.5). No grade 3 toxicities were reported. The oncological outcomes were similar in patients with early lung cancer treated with SBRT with or without biopsy-confirmation. In situations where tissue diagnosis is not feasible or unsafe, it is not unreasonable to offer SBRT based on clinical and radiological suspicion following multidisciplinary discussions.
DOI: 10.1111/ajco.13614
ORCID: 0000-0001-6828-6445
Journal: Asia-Pacific Journal of Clinical Oncology
PubMed URL: 34187094
Type: Journal Article
Subjects: biopsy confirmation
endobronchial ultrasound
lung cancer
stereotactic radiotherapy
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