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dc.contributor.authorKoh, Tze Lui-
dc.contributor.authorOng, Wee Loon-
dc.contributor.authorFarrugia, Briana-
dc.contributor.authorLeong, Tracy L-
dc.contributor.authorLapuz, Carminia-
dc.contributor.authorLim, Adeline-
dc.identifier.citationAsia-Pacific Journal of Clinical Oncology 2022-06; 18(3): 319-325en
dc.description.abstractObtaining tissue diagnosis for lung cancer can sometimes be difficult and unsafe. We evaluated outcomes of biopsy-confirmed versus radiologically-diagnosed lung cancer treated with stereotactic body radiotherapy (SBRT). A single-institutional retrospective cohort of lung cancer patients treated with SBRT between February 2014 and October 2018. Outcomes of interest were: local failure (LF), distant failure (DF), and overall survival (OS). Probability of LF, DF, and OS were estimated using the Kaplan-Meier method. Differences in outcomes between biopsy-confirmed versus radiologically-diagnosed lung cancer were evaluated using the log-rank test. Sixty-five lung lesions in 61 patients were treated with SBRT. Mean age was 75.6 years. Twenty-seven patients (44.3%) were ECOG 2-3. Thirty-nine patients (64%) were radiologically-diagnosed. There were five cases of LF observed at median of 12.8 months post-SBRT and 12-month LF-free survival was 96% (95% CI, 86-99%), with no differences between groups (p = 0.1). Sixteen patients developed DF, with 12-month DF-free survival of 84% (95% CI, 71-91%), and no difference between groups (p = 0.06). Sixteen deaths were reported at a median of 12.5 months post-SBRT, with 12-month OS of 85% (95% CI, 73-92%), and no differences between study groups (p = 0.5). No grade 3 toxicities were reported. The oncological outcomes were similar in patients with early lung cancer treated with SBRT with or without biopsy-confirmation. In situations where tissue diagnosis is not feasible or unsafe, it is not unreasonable to offer SBRT based on clinical and radiological suspicion following multidisciplinary discussions.en
dc.subjectbiopsy confirmationen
dc.subjectendobronchial ultrasounden
dc.subjectlung canceren
dc.subjectstereotactic radiotherapyen
dc.titleTo biopsy or not to biopsy? Outcomes following stereotactic body radiotherapy (SBRT) for biopsy-confirmed versus radiologically-diagnosed primary lung cancer in a single Australian institution.en
dc.typeJournal Articleen_US
dc.identifier.journaltitleAsia-Pacific Journal of Clinical Oncologyen
dc.identifier.affiliationSchool of Clinical Medicine, University of Cambridge, Cambridge, UKen
dc.identifier.affiliationCenter for Digital Transformation of Health, The University of Melbourne, Melbourne, VIC, Australiaen
dc.identifier.affiliationRespiratory and Sleep Medicineen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australiaen
dc.identifier.affiliationRadiation Oncologyen
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australiaen
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.pubmedid34187094-, Tze Lui
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone- Newton-John Cancer Wellness and Research Centre- Oncology- Oncology- Newton-John Cancer Wellness and Research Centre- and Sleep Medicine- for Breathing and Sleep- Oncology- Newton-John Cancer Wellness and Research Centre- Newton-John Cancer Wellness and Research Centre-
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