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Title: Tenecteplase vs Alteplase Before Endovascular Therapy in Basilar Artery Occlusion.
Austin Authors: Alemseged, Fana;Ng, Felix C ;Williams, Cameron;Puetz, Volker;Boulouis, Gregoire;Kleinig, Timothy John;Rocco, Alessandro;Wu, Teddy Y;Shah, Darshan;Arba, Francesco;Kaiser, Daniel;Di Giuliano, Francesca;Morotti, Andrea;Sallustio, Fabrizio;Dewey, Helen M;Bailey, Peter;O'Brien, Billy;Sharma, Gagan;Bush, Steven;Dowling, Richard;Diomedi, Marina;Churilov, Leonid ;Yan, Bernard;Parsons, Mark William;Davis, Stephen M;Mitchell, Peter J;Yassi, Nawaf;Campbell, Bruce C V
Affiliation: Department of Medicine and Neurology, University of Melbourne, Parkville, Australia
Department of Radiology, Royal Melbourne Hospital, Parkville, Australia
Stroke Unit, University Hospital of Tor Vergata, Rome, Italy
Department of Biomedicine and Prevention, University Hospital of Tor Vergata, Rome, Italy
Department of Neurology, Institute of Neuroradiology, and Dresden Neurovascular Center, University of Technology Dresden, Germany
Department of Interventional Neuroradiology, Sainte-Anne-Hospital, Paris, France
Department of Neurology, Royal Adelaide Hospital, Australia
Department of Neurology, Christchurch Hospital, New Zealand
Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia
NEUROFARBA Department, Careggi University Hospital, Florence
ASST Valcamonica, Department of Neurology, Esine, Italy
Department of Neurosciences, Eastern Health, Melbourne, Australia
Department of Neurology, Gold Coast University Hospital, Queensland, Australia
Department of Neurology, Gosford Hospital, New South Wales, Australia
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Issue Date: 2-Mar-2021
Date: 2021-01-06
Publication information: Neurology 2021; 96(9): e1272-e1277
Abstract: To investigate the efficacy of tenecteplase (TNK), a genetically modified variant of alteplase with greater fibrin specificity and longer half-life than alteplase, prior to endovascular thrombectomy (EVT) in patients with basilar artery occlusion (BAO). To determine whether TNK is associated with better reperfusion rates than alteplase prior to EVT in BAO, clinical and procedural data of consecutive patients with BAO from the Basilar Artery Treatment and Management (BATMAN) registry and the Tenecteplase vs Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK) trial were retrospectively analyzed. Reperfusion >50% or absence of retrievable thrombus at the time of the initial angiogram was evaluated. We included 110 patients with BAO treated with IV thrombolysis prior to EVT (mean age 69 [SD 14] years; median NIH Stroke Scale score 16 [interquartile range (IQR) 7-32]). Nineteen patients were thrombolysed with TNK (0.25 mg/kg or 0.40 mg/kg) and 91 with alteplase (0.9 mg/kg). Reperfusion >50% occurred in 26% (n = 5/19) of patients thrombolysed with TNK vs 7% (n = 6/91) thrombolysed with alteplase (risk ratio 4.0, 95% confidence interval 1.3-12; p = 0.02), despite shorter thrombolysis to arterial puncture time in the TNK-treated patients (48 [IQR 40-71] minutes) vs alteplase-treated patients (110 [IQR 51-185] minutes; p = 0.004). No difference in symptomatic intracranial hemorrhage was observed (0/19 [0%] TNK, 1/91 [1%] alteplase; p = 0.9). TNK may be associated with an increased rate of reperfusion in comparison with alteplase before EVT in BAO. Randomized controlled trials to compare TNK with alteplase in patients with BAO are warranted. NCT02388061 and NCT03340493. This study provides Class III evidence that TNK leads to higher reperfusion rates in comparison with alteplase prior to EVT in patients with BAO.
DOI: 10.1212/WNL.0000000000011520
ORCID: 0000-0001-8422-9205
Journal: Neurology
PubMed URL: 33408145
Type: Journal Article
Appears in Collections:Journal articles

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