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Title: Donor-specific cell-free DNA as a biomarker in liver transplantation: A review.
Austin Authors: McClure, Tess ;Goh, Su Kah ;Cox, Daniel R A ;Muralidharan, Vijayaragavan ;Dobrovic, Alexander ;Testro, Adam G 
Affiliation: Victorian Liver Transplant Unit
Surgery (University of Melbourne)
Issue Date: 28-Nov-2020 2020-11-28
Publication information: World Journal of Transplantation 2020; 10(11): 307-319
Abstract: Due to advances in modern medicine, liver transplantation has revolutionised the prognosis of many previously incurable liver diseases. This progress has largely been due to advances in immunosuppressant therapy. However, despite the judicious use of immunosuppression, many liver transplant recipients still experience complications such as rejection, which necessitates diagnosis via invasive liver biopsy. There is a clear need for novel, minimally-invasive tests to optimise immunosuppression and improve patient outcomes. An emerging biomarker in this ''precision medicine'' liver transplantation field is that of donor-specific cell free DNA. In this review, we detail the background and methods of detecting this biomarker, examine its utility in liver transplantation and discuss future research directions that may be most impactful.
DOI: 10.5500/wjt.v10.i11.307
PubMed URL: 33312892
ISSN: 2220-3230
Type: Journal Article
Subjects: Biomarkers
Donor-specific cell-free DNA
Liver transplantation
Precision medicine
Appears in Collections:Journal articles

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