Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25891
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dc.contributor.authorMcClure, Tess-
dc.contributor.authorGoh, Su Kah-
dc.contributor.authorCox, Daniel R A-
dc.contributor.authorMuralidharan, Vijayaragavan-
dc.contributor.authorDobrovic, Alexander-
dc.contributor.authorTestro, Adam G-
dc.date2020-11-28-
dc.date.accessioned2021-02-21T22:47:51Z-
dc.date.available2021-02-21T22:47:51Z-
dc.date.issued2020-11-28-
dc.identifier.citationWorld Journal of Transplantation 2020; 10(11): 307-319en
dc.identifier.issn2220-3230
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25891-
dc.description.abstractDue to advances in modern medicine, liver transplantation has revolutionised the prognosis of many previously incurable liver diseases. This progress has largely been due to advances in immunosuppressant therapy. However, despite the judicious use of immunosuppression, many liver transplant recipients still experience complications such as rejection, which necessitates diagnosis via invasive liver biopsy. There is a clear need for novel, minimally-invasive tests to optimise immunosuppression and improve patient outcomes. An emerging biomarker in this ''precision medicine'' liver transplantation field is that of donor-specific cell free DNA. In this review, we detail the background and methods of detecting this biomarker, examine its utility in liver transplantation and discuss future research directions that may be most impactful.en
dc.language.isoeng
dc.subjectBiomarkersen
dc.subjectDonor-specific cell-free DNAen
dc.subjectLiver transplantationen
dc.subjectPrecision medicineen
dc.subjectRejectionen
dc.subjectReviewen
dc.titleDonor-specific cell-free DNA as a biomarker in liver transplantation: A review.en
dc.typeJournal Articleen
dc.identifier.journaltitleWorld Journal of Transplantation en
dc.identifier.affiliationVictorian Liver Transplant Uniten
dc.identifier.affiliationSurgeryen
dc.identifier.affiliationSurgery (University of Melbourne)en
dc.identifier.doi10.5500/wjt.v10.i11.307en
dc.type.contentTexten
dc.identifier.pubmedid33312892
local.name.researcherCox, Daniel R A
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptVascular Surgery-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptSurgery-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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