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Title: Occlusive Disease and Upright Activity in Acute Ischemic Stroke.
Austin Authors: Carvalho, Lilian B;Chambers, Brian R ;Borschmann, Karen ;Kaffenberger, Tina;Churilov, Leonid ;Thijs, Vincent N ;Bernhardt, Julie
Affiliation: St Vincent's Hospital, Melbourne, Australia
Department of Medicine, University of Melbourne, Australia
Medicine (University of Melbourne)
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia
NHMRC Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery, Australia
Melbourne Brain Centre at Royal Melbourne Hospital, Melbourne Medical School, University of Melbourne, Australia
Issue Date: 18-Jan-2021 2021-01-18
Publication information: Journal of Stroke and Cerebrovascular Diseases 2021; 30(4): 105604
Abstract: The impact of out-of-bed upright activity on outcomes in ischemic stroke patients with severe extra- and intracranial stenosis or occlusion is unknown. Using ultrasound findings from a cohort recruited to A Very Early Rehabilitation Trial (AVERT) which compared higher dose very early mobilisation (VEM) to usual care (UC), we aimed to explore the association between occlusive disease and 3-month outcomes and occlusive disease-by-mobilisation treatment interactions. Participants with ischemic stroke, with carotid and transcranial Doppler ultrasounds performed ≤1 week after admission, were included in this single centre substudy in Melbourne, Australia. Reports were retrospectively reviewed to determine the degree of stenosis or presence of occlusion in the relevant arterial territory. Stenosis ≥70% extracranial or ≥50% intracranial were classified as severe or occlusion. Overall, 19% (n = 36/191) had occlusive disease in the affected circulation. About 40% (n = 14/36) with occlusive disease and 51% (n = 79/155) without had a 3-month favourable outcome (mRS 0-2) (adjusted OR0.53, CI0.17-1.67). Fourteen percent (n = 5) with occlusive disease and 4% (n = 6) without died by 3 months (adjusted OR2.52, CI0.6-10.7). Fifty percent (n = 11/22) of UC (adjusted OR0.86, CI0.23-3.2) and 21% (n = 3/14) of VEM participants (adjusted OR0.16, CI0.01-2.7) with occlusive disease had a favourable outcome. Almost 30% (n = 4) VEM participants with occlusive disease died (adjusted OR3.99, CI0.69-22.9) compared to 5% (n = 1) UC participants with occlusive disease (adjusted OR0.45, CI0.02-8.6), however numbers were small. No stenosis-by-treatment interactions were found. High quality prospective studies are needed to help guide decision making about when patients with occlusive disease should commence upright activity in acute stroke.
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105604
Journal: Journal of Stroke and Cerebrovascular Diseases
PubMed URL: 33476962
Type: Journal Article
Subjects: Occlusion
Sitting position
Standing position
Stroke recovery
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