Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/24918
Title: Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study.
Austin Authors: Gates, Priscilla ;Gough, Karla;Dhillon, Haryana;Wilson, Carlene J ;Hawkes, Eliza A ;Doré, Vincent ;Perchyonok, Yuliya ;Rowe, Christopher C ;Walker, Adam K;Vardy, Janette L;de Ruiter, Michiel;Krishnasamy, Meinir
Affiliation: Concord Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia
Concord Cancer Centre, Concord Repatriation and General Hospital, Concord, New South Wales, Australia
Centre for Medical Psychology & Evidence-based Decision-making, School of Psychology, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia
Research and Education Nursing, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia
Academic Nursing Unit, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cancer Nursing Research Group, Department of Nursing/Centre for Cancer Research, School of Health Sciences/University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia
School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
Laboratory of ImmunoPsychiatry, Neuroscience Research Australia, Sydney, New South Wales, Australia
Radiology
Molecular Imaging and Therapy
Olivia Newton-John Cancer Wellness and Research Centre
Biomedical Imaging, Health & Biosecurity Flagship, The Australian e-Health Research Centre, CSIRO Health & Biosecurity, Melbourne, Victoria, Australia
Department of Cancer Experiences, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Nursing, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia
Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia
Clinical Haematology
School of Psychology and Public Health, LaTrobe University, Melbourne, Victoria, Australia
Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands..
Olivia Newton-John Cancer Wellness and Research Centre
Issue Date: 29-Sep-2020
metadata.dc.date: 2020-09-29
Publication information: BMJ Open 2020; 10(9): e038312
Abstract: Cancer-related cognitive impairment (CRCI) is a distressing and disabling side-effect of cancer treatments affecting up to 75% of patients. For some patients, their cognitive impairment may be transient, but for a subgroup, these symptoms can be long-standing and have a major impact on the quality of life. This paper describes the protocol for a study: (1) to assess the feasibility of collecting longitudinal data on cognition via self-report, neuropsychological testing, peripheral markers of inflammation and neuroimaging and (2) to explore and describe patterns of cancer-related cognitive impairment over the course of treatment and recovery in patients with newly diagnosed, aggressive lymphoma undergoing standard therapy with curative intent. This is a prospective, longitudinal, feasibility study in which 30 newly diagnosed, treatment-naive patients with aggressive lymphoma will be recruited over a 12-month period. Patients will complete comprehensive assessments at three time points: baseline (time 1, pre-treatment) and two post-baseline follow-up assessments (time 2, mid-treatment and time 3, 6-8 weeks post-treatment completion). All patients will be assessed for self-reported cognitive difficulties and objective cognitive function using Stroop Colour and Word, Trail Making Test Part A and B, Hopkins Verbal Learning Test-Revised, Controlled Oral Word Association and Digit Span. Blood cell-based inflammatory markers and neuroimaging including a positron emission tomography (PET) with 18F-labelled fluoro-2-deoxyglucose (18F-FDG) and CT (18F-FDG-PET/CT) and a MRI will explore potential inflammatory and neuroanatomical or functional mechanisms and biomarkers related to CRCI. The primary intent of analysis will be to assess the feasibility of collecting longitudinal data on cognition using subjective reports and objective tasks from patients during treatment and recovery for lymphoma. These data will inform the design of a larger-scale investigation into the patterns of cognitive change over the course of treatment and recovery, adding to an underexplored area of cancer survivorship research. Ethical approval has been granted by Austin Health Human Rights Ethics Committee (HREC) in Victoria Australia. Peer reviewed publications and conference presentations will report the findings of this novel study. Australian New Zealand Clinical Trials Registry (ACTRN12619001649101).
URI: https://ahro.austin.org.au/austinjspui/handle/1/24918
DOI: 10.1136/bmjopen-2020-038312
ORCID: 0000-0002-7978-5802
0000-0003-2819-4217
0000-0003-4039-5169
0000-0002-1883-4690
0000-0002-0376-2559
0000-0002-8051-0558
0000-0003-3476-8766
0000-0003-3910-2453
0000-0001-7954-5801
0000-0002-5739-5790
0000-0002-3050-4213
PubMed URL: 32994248
Type: Journal Article
Subjects: adult neurology
delirium & cognitive disorders
lymphoma
Appears in Collections:Journal articles

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