Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/24918
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dc.contributor.authorGates, Priscilla-
dc.contributor.authorGough, Karla-
dc.contributor.authorDhillon, Haryana-
dc.contributor.authorWilson, Carlene J-
dc.contributor.authorHawkes, Eliza A-
dc.contributor.authorDoré, Vincent-
dc.contributor.authorPerchyonok, Yuliya-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorWalker, Adam K-
dc.contributor.authorVardy, Janette L-
dc.contributor.authorde Ruiter, Michiel-
dc.contributor.authorKrishnasamy, Meinir-
dc.date2020-09-29-
dc.date.accessioned2020-10-02T03:26:50Z-
dc.date.available2020-10-02T03:26:50Z-
dc.date.issued2020-09-29-
dc.identifier.citationBMJ Open 2020; 10(9): e038312en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/24918-
dc.description.abstractCancer-related cognitive impairment (CRCI) is a distressing and disabling side-effect of cancer treatments affecting up to 75% of patients. For some patients, their cognitive impairment may be transient, but for a subgroup, these symptoms can be long-standing and have a major impact on the quality of life. This paper describes the protocol for a study: (1) to assess the feasibility of collecting longitudinal data on cognition via self-report, neuropsychological testing, peripheral markers of inflammation and neuroimaging and (2) to explore and describe patterns of cancer-related cognitive impairment over the course of treatment and recovery in patients with newly diagnosed, aggressive lymphoma undergoing standard therapy with curative intent. This is a prospective, longitudinal, feasibility study in which 30 newly diagnosed, treatment-naive patients with aggressive lymphoma will be recruited over a 12-month period. Patients will complete comprehensive assessments at three time points: baseline (time 1, pre-treatment) and two post-baseline follow-up assessments (time 2, mid-treatment and time 3, 6-8 weeks post-treatment completion). All patients will be assessed for self-reported cognitive difficulties and objective cognitive function using Stroop Colour and Word, Trail Making Test Part A and B, Hopkins Verbal Learning Test-Revised, Controlled Oral Word Association and Digit Span. Blood cell-based inflammatory markers and neuroimaging including a positron emission tomography (PET) with 18F-labelled fluoro-2-deoxyglucose (18F-FDG) and CT (18F-FDG-PET/CT) and a MRI will explore potential inflammatory and neuroanatomical or functional mechanisms and biomarkers related to CRCI. The primary intent of analysis will be to assess the feasibility of collecting longitudinal data on cognition using subjective reports and objective tasks from patients during treatment and recovery for lymphoma. These data will inform the design of a larger-scale investigation into the patterns of cognitive change over the course of treatment and recovery, adding to an underexplored area of cancer survivorship research. Ethical approval has been granted by Austin Health Human Rights Ethics Committee (HREC) in Victoria Australia. Peer reviewed publications and conference presentations will report the findings of this novel study. Australian New Zealand Clinical Trials Registry (ACTRN12619001649101).en
dc.language.isoeng-
dc.subjectadult neurologyen
dc.subjectdelirium & cognitive disordersen
dc.subjectlymphomaen
dc.titleLongitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study.en
dc.typeJournal Articleen
dc.identifier.journaltitleBMJ Openen
dc.identifier.affiliationConcord Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australiaen
dc.identifier.affiliationDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlandsen
dc.identifier.affiliationConcord Cancer Centre, Concord Repatriation and General Hospital, Concord, New South Wales, Australiaen
dc.identifier.affiliationCentre for Medical Psychology & Evidence-based Decision-making, School of Psychology, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australiaen
dc.identifier.affiliationResearch and Education Nursing, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationAcademic Nursing Unit, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCancer Nursing Research Group, Department of Nursing/Centre for Cancer Research, School of Health Sciences/University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australiaen
dc.identifier.affiliationLaboratory of ImmunoPsychiatry, Neuroscience Research Australia, Sydney, New South Wales, Australiaen
dc.identifier.affiliationRadiologyen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.affiliationBiomedical Imaging, Health & Biosecurity Flagship, The Australian e-Health Research Centre, CSIRO Health & Biosecurity, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Cancer Experiences, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Nursing, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationFaculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationClinical Haematologyen
dc.identifier.affiliationSchool of Psychology and Public Health, LaTrobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.doi10.1136/bmjopen-2020-038312en
dc.type.contentTexten
dc.identifier.orcid0000-0002-7978-5802en
dc.identifier.orcid0000-0003-2819-4217en
dc.identifier.orcid0000-0003-4039-5169en
dc.identifier.orcid0000-0002-1883-4690en
dc.identifier.orcid0000-0002-0376-2559en
dc.identifier.orcid0000-0002-8051-0558en
dc.identifier.orcid0000-0003-3476-8766en
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.orcid0000-0001-7954-5801en
dc.identifier.orcid0000-0002-5739-5790en
dc.identifier.orcid0000-0002-3050-4213en
dc.identifier.pubmedid32994248-
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