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Title: Biomechanical leg muscle function during stair ambulation in men receiving androgen deprivation therapy.
Austin Authors: Cheung, Ada S ;Gray, Hans A;Schache, Anthony G;Hoermann, Rudolf;Bicknell, Jarrod;Lim Joon, Daryl ;Zajac, Jeffrey D ;Pandy, Marcus G;Grossmann, Mathis 
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Mechanical Engineering, The University of Melbourne, Victoria, Australia
Department of Endocrinology, The University of Melbourne, Victoria, Australia
Department of Radiation Oncology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 16-Sep-2020 2019-07-16
Publication information: The journals of gerontology. Series A, Biological sciences and medical sciences 2020; 75(9): 1715-1722
Abstract: The role of testosterone in maintaining functional performance in older men remains uncertain. We conducted a 12-month prospective, observational case-control study including 34 men newly commencing androgen deprivation therapy (ADT) for prostate cancer and 29 age-matched prostate cancer controls. Video-based motion capture and ground reaction force data combined with computational musculoskeletal modelling, and data were analysed with a linear mixed model. Compared to controls over 12 months, men receiving ADT had a mean reduction in circulating testosterone from 14.1nmol/L to 0.4nmol/L, associated with reductions in peak knee extension torque, mean adjusted difference (MAD) -0.07 Nm/kg [95%CI -0.18, 0.04], p=0.009, with a corresponding more marked decrease in quadriceps force MAD -0.11 x body weight (BW) [-0.27, 0.06], p=0.045 (equating to a 9 kg force reduction for the mean BW of 85 kg), and decreased maximal contribution of quadriceps to upward propulsion, MAD -0.47 m/s2 [-0.95, 0.02], p=0.009. We observed between group differences in several other parameters, including increased gluteus maximus force in men receiving ADT, MAD 0.11xBW [0.02, 0.20], p=0.043, which may be compensatory. Severe testosterone deprivation over 12 months is associated with selective deficits in lower limb function evident with an important task of daily living.
DOI: 10.1093/gerona/glz169
ORCID: 0000-0001-5257-5525
PubMed URL: 31310271
Type: Journal Article
Subjects: Androgen deprivation
muscle function
Prostate cancer
Appears in Collections:Journal articles

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