Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21405
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dc.contributor.authorCheung, Ada S-
dc.contributor.authorGray, Hans A-
dc.contributor.authorSchache, Anthony G-
dc.contributor.authorHoermann, Rudolf-
dc.contributor.authorBicknell, Jarrod-
dc.contributor.authorLim Joon, Daryl-
dc.contributor.authorZajac, Jeffrey D-
dc.contributor.authorPandy, Marcus G-
dc.contributor.authorGrossmann, Mathis-
dc.date2019-07-16-
dc.date.accessioned2019-08-12T05:00:10Z-
dc.date.available2019-08-12T05:00:10Z-
dc.date.issued2020-09-16-
dc.identifier.citationThe journals of gerontology. Series A, Biological sciences and medical sciences 2020; 75(9): 1715-1722en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/21405-
dc.description.abstractThe role of testosterone in maintaining functional performance in older men remains uncertain. We conducted a 12-month prospective, observational case-control study including 34 men newly commencing androgen deprivation therapy (ADT) for prostate cancer and 29 age-matched prostate cancer controls. Video-based motion capture and ground reaction force data combined with computational musculoskeletal modelling, and data were analysed with a linear mixed model. Compared to controls over 12 months, men receiving ADT had a mean reduction in circulating testosterone from 14.1nmol/L to 0.4nmol/L, associated with reductions in peak knee extension torque, mean adjusted difference (MAD) -0.07 Nm/kg [95%CI -0.18, 0.04], p=0.009, with a corresponding more marked decrease in quadriceps force MAD -0.11 x body weight (BW) [-0.27, 0.06], p=0.045 (equating to a 9 kg force reduction for the mean BW of 85 kg), and decreased maximal contribution of quadriceps to upward propulsion, MAD -0.47 m/s2 [-0.95, 0.02], p=0.009. We observed between group differences in several other parameters, including increased gluteus maximus force in men receiving ADT, MAD 0.11xBW [0.02, 0.20], p=0.043, which may be compensatory. Severe testosterone deprivation over 12 months is associated with selective deficits in lower limb function evident with an important task of daily living.en_US
dc.language.isoeng-
dc.subjectAndrogen deprivationen_US
dc.subjectkinematicsen_US
dc.subjectmuscle functionen_US
dc.subjectProstate canceren_US
dc.subjectsarcopeniaen_US
dc.titleBiomechanical leg muscle function during stair ambulation in men receiving androgen deprivation therapy.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleThe journals of gerontology. Series A, Biological sciences and medical sciencesen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationDepartment of Mechanical Engineering, The University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Endocrinology, The University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationRadiation Oncologyen_US
dc.identifier.doi10.1093/gerona/glz169en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-5257-5525en_US
dc.identifier.orcid0000-0002-1326-4270en_US
dc.identifier.orcid0000-0002-1947-9694en_US
dc.identifier.orcid0000-0003-3933-5708en_US
dc.identifier.orcid0000-0001-8261-3457en_US
dc.identifier.pubmedid31310271-
dc.type.austinJournal Article-
local.name.researcherCheung, Ada S
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
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