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Title: A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke.
Austin Authors: Hayward, Kathryn S ;Kramer, Sharon F ;Thijs, Vincent N ;Ratcliffe, Julie;Ward, Nick S;Churilov, Leonid ;Jolliffe, Laura;Corbett, Dale;Cloud, Geoffrey;Kaffenberger, Tina;Brodtmann, Amy ;Bernhardt, Julie;Lannin, Natasha A
Affiliation: AVERT Early Rehabilitation Research Group, Stroke Theme, Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia
Department of Neurosurgery, Austin Health, Heidelberg, Victoria, Australia
Department of Cellular and Molecular Medicine, University of Ottawa and Canadian Partnership for Stroke Recovery, Ottawa, Canada
College of Science, Health and Engineering, La Trobe University, Bundoora, Melbourne, Victoria, Australia
Department of Neurology, Alfred Health, Prahran, Melbourne, Victoria, Australia
Eastern Clinical Research Unit and Neurology Department, Eastern Health, Melbourne, Victoria, Australia
Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
NHMRC CRE in Stroke Rehabilitation and Brain Recovery, University of Melbourne, Heidelberg, Melbourne, Victoria, 3084, Australia
School of Allied Health (Occupational Therapy), La Trobe University, Bundoora, Melbourne, Victoria, Australia
Occupational Therapy Department, Alfred Health, Prahran, Melbourne, Victoria, Australia
College of Nursing and Health Sciences, Flinders University, Adelaide, Australia
Melbourne Medical School, University of Melbourne, Parkville, Melbourne, Australia
Stroke Theme, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
The Department of Clinical Neuroscience, Central Clinical School, Monash University, Melbourne, Australia
UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
Melbourne School of Health Sciences, University of Melbourne, Parkville, Melbourne, Australia
Issue Date: 25-Jul-2019
Date: 2019-07-25
Publication information: Systematic reviews 2019; 8(1): 187
Abstract: Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to complete three systematic reviews to estimate the (1) association between time to start of UL therapy and motor recovery, (2) relative efficacy of different UL therapy approaches post-stroke and (3) cost-effectiveness of UL therapy interventions. We have designed a systematic review protocol to address three systematic review questions that were each registered with PROSPERO. The search will be conducted in MEDLINE, EMBASE, and Cochrane Controlled Register of Trials. We will include randomised controlled trials, non-randomised clinical trials, before-after studies and observational studies of adult stroke survivors with an average stroke onset < 6 months, undergoing hospital-based therapy to improve UL function. Eligible interventions will aim to promote UL functional recovery. Two reviewers will independently screen, select and extract data. Study risk of bias will be appraised using appropriate tools. Clinical measures of motor recovery will be investigated (primary measure Fugl Meyer UL assessment), as well as measures of health-related quality of life (primary measure EQ-5D) and all cost-effectiveness analyses completed. Secondary outcomes include therapy dose (minutes, weeks, repetitions as available) and safety (i.e. adverse events, serious adverse events). A narrative synthesis will describe quality and content of the evidence. If feasible, we will conduct random effects meta-analyses where appropriate. We anticipate the findings of this review will increase our understanding of UL therapy and inform the generation of novel, data-driven hypotheses for future UL therapy research post-stroke. PROSPERO,,,
DOI: 10.1186/s13643-019-1093-6
ORCID: 0000-0001-5240-3264
Journal: Systematic reviews
PubMed URL: 31345263
Type: Journal Article
Subjects: Protocol
Systematic review
Upper limb
Appears in Collections:Journal articles

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