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Title: Mycophenolate mofetil toxicity mimicking acute cellular rejection in a small intestinal transplant.
Austin Authors: Apostolov, Ross ;Asadi, Khashayar ;Lokan, Julie ;Kam, Ning;Testro, Adam G 
Affiliation: Australian Intestinal Transplant Service, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 24-Feb-2017
Publication information: World Journal of Transplantation 2017; 7(1): 98-102
Abstract: Mycophenolate mofetil (MMF) is an important medication used for maintenance immunosuppression in solid organ transplants. A common gastrointestinal (GI) side effect of MMF is enterocolitis, which has been associated with multiple histological features. There is little data in the literature describing the histological effects of MMF in small intestinal transplant (SIT) recipients. We present a case of MMF toxicity in a SIT recipient, with histological changes in the donor ileum mimicking persistent acute cellular rejection (ACR). Concurrent biopsies of the patient's native colon showed similar changes to those from the donor small bowel, suggesting a non-graft specific process, raising suspicion for MMF toxicity. The MMF was discontinued and complete resolution of these changes occurred over three weeks. MMF toxicity should therefore be considered as a differential diagnosis for ACR and graft-versus-host disease in SITs.
DOI: 10.5500/wjt.v7.i1.98
Journal: World Journal of Transplantation
PubMed URL: 28280702
ISSN: 2220-3230
Type: Journal Article
Subjects: Acute cellular rejection
Drug toxicity
Mycophenolate mofetil
Small intestinal transplantation
Appears in Collections:Journal articles

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