Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/19066
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dc.contributor.authorApostolov, Ross-
dc.contributor.authorAsadi, Khashayar-
dc.contributor.authorLokan, Julie-
dc.contributor.authorKam, Ning-
dc.contributor.authorTestro, Adam G-
dc.date.accessioned2018-09-13T00:14:47Z-
dc.date.available2018-09-13T00:14:47Z-
dc.date.issued2017-02-24-
dc.identifier.citationWorld Journal of Transplantation 2017; 7(1): 98-102en
dc.identifier.issn2220-3230-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/19066-
dc.description.abstractMycophenolate mofetil (MMF) is an important medication used for maintenance immunosuppression in solid organ transplants. A common gastrointestinal (GI) side effect of MMF is enterocolitis, which has been associated with multiple histological features. There is little data in the literature describing the histological effects of MMF in small intestinal transplant (SIT) recipients. We present a case of MMF toxicity in a SIT recipient, with histological changes in the donor ileum mimicking persistent acute cellular rejection (ACR). Concurrent biopsies of the patient's native colon showed similar changes to those from the donor small bowel, suggesting a non-graft specific process, raising suspicion for MMF toxicity. The MMF was discontinued and complete resolution of these changes occurred over three weeks. MMF toxicity should therefore be considered as a differential diagnosis for ACR and graft-versus-host disease in SITs.en
dc.language.isoeng-
dc.subjectAcute cellular rejectionen
dc.subjectDrug toxicityen
dc.subjectImmunosuppressionen
dc.subjectMycophenolate mofetilen
dc.subjectSmall intestinal transplantationen
dc.titleMycophenolate mofetil toxicity mimicking acute cellular rejection in a small intestinal transplant.en
dc.typeJournal Articleen
dc.identifier.journaltitleWorld Journal of Transplantation en
dc.identifier.affiliationAustralian Intestinal Transplant Service, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.5500/wjt.v7.i1.98en
dc.type.contentTexten
dc.identifier.pubmedid28280702-
dc.type.austinJournal Article-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptPathology-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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