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Title: Subjective Memory Complaints in APOEɛ4 Carriers are Associated with High Amyloid-β Burden.
Austin Authors: Zwan, Marissa D;Villemagne, Victor L ;Doré, Vincent ;Buckley, Rachel;Bourgeat, Pierrick;Veljanoski, Robyn;Salvado, Olivier;Williams, Rob;Margison, Laura ;Rembach, Alan;Macaulay, S Lance;Martins, Ralph;Ames, David;van der Flier, Wiesje M;Ellis, Kathryn A;Scheltens, Philip;Masters, Colin L ;Rowe, Christopher C 
Affiliation: Department of Epidemiology and Biostatistics, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
National Ageing Research Institute, Parkville, Victoria, Australia
Department of Psychiatry, The University of Melbourne, Victoria, Australia
Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia
CSIRO Digital Productivity Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, Queensland, Australia
Melbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia
CSIRO Food and Nutrion Flagship, Parkville, Victoria, Australia
Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Issue Date: 2016
Publication information: Journal of Alzheimer's disease : JAD 2016; 49(4): 1115-1122
Abstract: APOEɛ4 genotype and aging have been identified as risk factors for Alzheimer's disease (AD). In addition, subjective memory complaints (SMC) might be a first clinical expression of the effect of AD pathology on cognitive functioning. To assess whether APOEɛ4 genotype, age, SMC, and episodic memory are risk factors for high amyloid-β (Aβ) burden in cognitively normal elderly. 307 cognitively normal participants (72.7 ± 6.8 years, 53% female, 55% SMC) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent amyloid PET and APOE genotyping. Logistic regression analyses were performed to determine the association of APOEɛ4 genotype, age, SMC, and episodic memory with Aβ pathology. Odds of high Aβ burden were greater at an older age (OR = 3.21; 95% CI = 1.68-6.14), when SMC were present (OR = 1.90; 95% CI = 1.03-3.48), and for APOEɛ4 carriers (OR = 7.49; 95% CI = 3.96-14.15), while episodic memory was not associated with odds of high Aβ burden. Stratified analyses showed that odds of SMC for high Aβ burden were increased in specifically APOEɛ4 carriers (OR = 4.58, 95% CI = 1.83-11.49) and younger participants (OR = 3.73, 95% CI = 1.39-10.01). Aging, APOEɛ4 genotype, and SMC were associated with high Aβ burden. SMC were especially indicative of high Aβ burden in younger participants and in APOEɛ4 carriers. These findings suggest that selection based on the presence of SMC, APOEɛ4 genotype and age may help identify healthy elderly participants with high Aβ burden eligible for secondary prevention trials.
DOI: 10.3233/JAD-150446
ORCID: 0000-0003-3910-2453
Journal: Journal of Alzheimer's disease : JAD
PubMed URL: 26639956
Type: Journal Article
Subjects: Aging
apolipoprotein E
episodic memory
positron emission tomography
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