Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18682
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dc.contributor.authorZwan, Marissa D-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorDoré, Vincent-
dc.contributor.authorBuckley, Rachel-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorVeljanoski, Robyn-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorWilliams, Rob-
dc.contributor.authorMargison, Laura-
dc.contributor.authorRembach, Alan-
dc.contributor.authorMacaulay, S Lance-
dc.contributor.authorMartins, Ralph-
dc.contributor.authorAmes, David-
dc.contributor.authorvan der Flier, Wiesje M-
dc.contributor.authorEllis, Kathryn A-
dc.contributor.authorScheltens, Philip-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.date.accessioned2018-08-30T06:44:23Z-
dc.date.available2018-08-30T06:44:23Z-
dc.date.issued2016-
dc.identifier.citationJournal of Alzheimer's disease : JAD 2016; 49(4): 1115-1122en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18682-
dc.description.abstractAPOEɛ4 genotype and aging have been identified as risk factors for Alzheimer's disease (AD). In addition, subjective memory complaints (SMC) might be a first clinical expression of the effect of AD pathology on cognitive functioning. To assess whether APOEɛ4 genotype, age, SMC, and episodic memory are risk factors for high amyloid-β (Aβ) burden in cognitively normal elderly. 307 cognitively normal participants (72.7 ± 6.8 years, 53% female, 55% SMC) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent amyloid PET and APOE genotyping. Logistic regression analyses were performed to determine the association of APOEɛ4 genotype, age, SMC, and episodic memory with Aβ pathology. Odds of high Aβ burden were greater at an older age (OR = 3.21; 95% CI = 1.68-6.14), when SMC were present (OR = 1.90; 95% CI = 1.03-3.48), and for APOEɛ4 carriers (OR = 7.49; 95% CI = 3.96-14.15), while episodic memory was not associated with odds of high Aβ burden. Stratified analyses showed that odds of SMC for high Aβ burden were increased in specifically APOEɛ4 carriers (OR = 4.58, 95% CI = 1.83-11.49) and younger participants (OR = 3.73, 95% CI = 1.39-10.01). Aging, APOEɛ4 genotype, and SMC were associated with high Aβ burden. SMC were especially indicative of high Aβ burden in younger participants and in APOEɛ4 carriers. These findings suggest that selection based on the presence of SMC, APOEɛ4 genotype and age may help identify healthy elderly participants with high Aβ burden eligible for secondary prevention trials.en
dc.language.isoeng-
dc.subjectAgingen
dc.subject[11C]-PiBen
dc.subject[18F]flutemetamolen
dc.subjectamyloid-βen
dc.subjectapolipoprotein Een
dc.subjectepisodic memoryen
dc.subjectpositron emission tomographyen
dc.titleSubjective Memory Complaints in APOEɛ4 Carriers are Associated with High Amyloid-β Burden.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Alzheimer's disease : JADen
dc.identifier.affiliationDepartment of Epidemiology and Biostatistics, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlandsen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlandsen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationCSIRO Digital Productivity Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, Queensland, Australiaen
dc.identifier.affiliationMelbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationCSIRO Food and Nutrion Flagship, Parkville, Victoria, Australiaen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.doi10.3233/JAD-150446en
dc.type.contentTexten
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.pubmedid26639956-
dc.type.austinJournal Article-
dc.type.austinResearch Support, Non-U.S. Gov't-
local.name.researcherDoré, Vincent
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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