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Title: Efficacy of oral vancomycin in recurrent primary sclerosing cholangitis following liver transplantation.
Austin Authors: Hey, Penelope ;Lokan, Julie ;Johnson, Paul D R ;Gow, Paul
Affiliation: Gastroenterology and Hepatology
Infectious Diseases
Issue Date: 25-Sep-2017
Date: 2017
Publication information: BMJ Case Reports 2017; 2017: bcr-2017-221165
Abstract: Primary sclerosing cholangitis (PSC) is a liver disease that leads to progressive destruction and stricturing of the biliary tree. Unfortunately, apart from orthotopic liver transplantation (OLT), there are no universally accepted therapies to treat this disease. Even following transplantation, recurrence of PSC is seen in approximately one quarter of patients and leads to high rates of graft failure. Oral vancomycin, through possible immunomodulatory and anti-inflammatory mechanisms, has been shown in small-scale studies to be successful in improving liver function tests in patients with pretransplant PSC. We report the first case of an adult patient diagnosed with recurrent PSC 4 years after OLT who was treated with oral vancomycin leading to complete normalisation of his liver biochemistry. This case adds to the growing literature of a potential therapeutic role for this antibiotic in PSC and highlights interesting questions regarding mechanisms of disease.
DOI: 10.1136/bcr-2017-221165
Journal: BMJ Case Reports
PubMed URL: 28951512
Type: Journal Article
Subjects: biliary intervention
portal hypertension
Appears in Collections:Journal articles

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