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Title: | Timely initiation of chemotherapy: a systematic literature review in six priority cancers - results and recommendations for clinical practice | Austin Authors: | Alexander, Marliese;Blum, Robert;Burbury, Kate;Coutsouvelis, John;Dooley, Michael J;Fazil, Obaid;Griffitths, Tina;Ismail, Huda;Joshi, Sachin;Love, Natalie;Opat, Stephen;Parente, Phillip;Porter, Nicole;Ross, Eldene;Siderov, Jim ;Thomas, Pauline;White, Shane ;Kirsa, Sue;Rischin, Danny | Affiliation: | Pharmacy Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia Department of Medical Oncology, Bendigo Health, Bendigo, Victoria, Australia Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia Pharmacy Department, Monash Health, Clayton, Victoria, Australia Olivia Newton-John Cancer & Wellness Centre, Austin Health, Heidelberg, Victoria, Australia Pharmacy Department, Royal Women's Hospital, Melbourne, Victoria, Australia Department of Medical Oncology, Latrobe Regional Hospital, Traralgon, Victoria, Australia Department of Nursing, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Clinical Haematology, Monash Health, Clayton, Victoria, Australia Department of Medical Oncology, Eastern Health, Box Hill, Victoria, Australia Monash University, Clayton, Victoria, Australia Division of Neurosciences, Cancer & Infection Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia Department of Nursing, Royal Women's Hospital, Melbourne, Victoria, Australia Department of Medical Oncology, Northern Hospital, Epping, Victoria, Australia Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia |
Issue Date: | Jan-2017 | Date: | 2016-07-11 | Publication information: | Internal Medicine Journal 2017; 47(1): 16-34 | Abstract: | This review evaluated the association between time-to-chemotherapy (TTC) and survival in six priority cancers. A systematic review of the literature was undertaken for papers indexed in MEDLINE and Cochrane Library databases from earliest index until April 2014. The methodology used has been published in a separate paper (Timely initiation of chemotherapy. Part 1: a proposed framework for access to medical oncology and haematology cancer clinics and chemotherapy services). The optimal timing of chemotherapy in breast cancer is unclear as available studies are of low quality, report inconsistent results, and are limited to the adjuvant setting. However, increased TTC may have a negative prognostic impact and delays beyond 4 weeks should be avoided. Studies suggest that the optimal timing for initiation of adjuvant chemotherapy for surgically resected colorectal cancer is 4-8 weeks post-surgery. Timing of chemotherapy for metastatic colorectal cancer does not influence survival. There is a paucity of studies to guide the timing of chemotherapy for the treatment of lymphoma and myeloma; no definitive conclusions can be drawn and clinician discretion should be applied. The optimal timing of chemotherapy in lung cancer is unclear; however, rapid tumour growth and poor disease prognosis suggest that delays should be avoided wherever possible. The optimal timing of chemotherapy in ovarian cancer is unclear as available studies are of low level, report inconsistent results, and are limited to the post surgery setting; however, increased TTC may have a negative prognostic impact, therefore; delays beyond 4 weeks should be avoided. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/16112 | DOI: | 10.1111/imj.13190 | Journal: | Internal Medicine Journal | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/27396268 | Type: | Journal Article | Subjects: | Cancer Chemotherapy Drug therapy Quality indicator Timely |
Type of Clinical Study or Trial: | Systematic Reviews |
Appears in Collections: | Journal articles |
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