Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16112
Title: Timely initiation of chemotherapy: a systematic literature review in six priority cancers - results and recommendations for clinical practice
Austin Authors: Alexander, Marliese;Blum, Robert;Burbury, Kate;Coutsouvelis, John;Dooley, Michael J;Fazil, Obaid;Griffitths, Tina;Ismail, Huda;Joshi, Sachin;Love, Natalie;Opat, Stephen;Parente, Phillip;Porter, Nicole;Ross, Eldene;Siderov, Jim ;Thomas, Pauline;White, Shane ;Kirsa, Sue;Rischin, Danny
Affiliation: Pharmacy Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Department of Medical Oncology, Bendigo Health, Bendigo, Victoria, Australia
Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia
Pharmacy Department, Monash Health, Clayton, Victoria, Australia
Olivia Newton-John Cancer & Wellness Centre, Austin Health, Heidelberg, Victoria, Australia
Pharmacy Department, Royal Women's Hospital, Melbourne, Victoria, Australia
Department of Medical Oncology, Latrobe Regional Hospital, Traralgon, Victoria, Australia
Department of Nursing, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Clinical Haematology, Monash Health, Clayton, Victoria, Australia
Department of Medical Oncology, Eastern Health, Box Hill, Victoria, Australia
Monash University, Clayton, Victoria, Australia
Division of Neurosciences, Cancer & Infection Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia
Department of Nursing, Royal Women's Hospital, Melbourne, Victoria, Australia
Department of Medical Oncology, Northern Hospital, Epping, Victoria, Australia
Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Issue Date: Jan-2017
metadata.dc.date: 2016-07-11
Publication information: Internal Medicine Journal 2017; 47(1): 16-34
Abstract: This review evaluated the association between time-to-chemotherapy (TTC) and survival in six priority cancers. A systematic review of the literature was undertaken for papers indexed in MEDLINE and Cochrane Library databases from earliest index until April 2014. The methodology used has been published in a separate paper (Timely initiation of chemotherapy. Part 1: a proposed framework for access to medical oncology and haematology cancer clinics and chemotherapy services). The optimal timing of chemotherapy in breast cancer is unclear as available studies are of low quality, report inconsistent results, and are limited to the adjuvant setting. However, increased TTC may have a negative prognostic impact and delays beyond 4 weeks should be avoided. Studies suggest that the optimal timing for initiation of adjuvant chemotherapy for surgically resected colorectal cancer is 4-8 weeks post-surgery. Timing of chemotherapy for metastatic colorectal cancer does not influence survival. There is a paucity of studies to guide the timing of chemotherapy for the treatment of lymphoma and myeloma; no definitive conclusions can be drawn and clinician discretion should be applied. The optimal timing of chemotherapy in lung cancer is unclear; however, rapid tumour growth and poor disease prognosis suggest that delays should be avoided wherever possible. The optimal timing of chemotherapy in ovarian cancer is unclear as available studies are of low level, report inconsistent results, and are limited to the post surgery setting; however, increased TTC may have a negative prognostic impact, therefore; delays beyond 4 weeks should be avoided.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16112
DOI: 10.1111/imj.13190
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/27396268
Type: Journal Article
Subjects: Cancer
Chemotherapy
Drug therapy
Quality indicator
Timely
Type of Clinical Study or Trial: Systematic Reviews
Appears in Collections:Journal articles

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