Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16061
Title: Activation of medulla-projecting perifornical neurons modulates the adrenal sympathetic response to hypoglycemia: involvement of orexin type 2 (OX2-R) receptors
Austin Authors: Korim, Willian S;Llewellyn-Smith, Ida J;Verberne, Anthony J M 
Affiliation: Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia
Cardiovascular Medicine, Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University, Bedford Park, South Australia, Australia
Issue Date: Feb-2016
metadata.dc.date: 2015-12-11
Publication information: Endocrinology 2016; 157(2): 810-819
Abstract: Iatrogenic hypoglycemia in response to insulin treatment is commonly experienced by patients with type 1 diabetes and can be life threatening. The body releases epinephrine in an attempt to counterregulate hypoglycemia, but the neural mechanisms underlying this phenomenon remain to be elucidated. Orexin neurons in the perifornical hypothalamus (PeH) project to the rostral ventrolateral medulla (RVLM) and are likely to be involved in epinephrine secretion during hypoglycemia. In anesthetized rats, we report that hypoglycemia increases the sympathetic preganglionic discharge to the adrenal gland by activating PeH orexin neurons that project to the RVLM (PeH-RVLM). Electrophysiological characterization shows that the majority of identified PeH-RVLM neurons, including a subpopulation of orexin neurons, are activated in response to hypoglycemia or glucoprivation. Furthermore, the excitatory input from the PeH is mediated by orexin type 2 receptors in the RVLM. These results suggest that activation of orexin PeH-RVLM neurons and orexin type 2 receptors in the RVLM facilitates epinephrine release by increasing sympathetic drive to adrenal chromaffin cells during hypoglycemia.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16061
DOI: 10.1210/en.2015-1712
ORCID: 0000-0002-2049-1439
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/26653571
Type: Journal Article
Subjects: Adrenal Glands
Epinephrine
Hypoglycemia
Hypothalamus
Medulla Oblongata
Neurons
Orexin Receptors
Appears in Collections:Journal articles

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