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dc.contributor.authorKorim, Willian S-
dc.contributor.authorLlewellyn-Smith, Ida J-
dc.contributor.authorVerberne, Anthony J M-
dc.identifier.citationEndocrinology 2016; 157(2): 810-819en_US
dc.description.abstractIatrogenic hypoglycemia in response to insulin treatment is commonly experienced by patients with type 1 diabetes and can be life threatening. The body releases epinephrine in an attempt to counterregulate hypoglycemia, but the neural mechanisms underlying this phenomenon remain to be elucidated. Orexin neurons in the perifornical hypothalamus (PeH) project to the rostral ventrolateral medulla (RVLM) and are likely to be involved in epinephrine secretion during hypoglycemia. In anesthetized rats, we report that hypoglycemia increases the sympathetic preganglionic discharge to the adrenal gland by activating PeH orexin neurons that project to the RVLM (PeH-RVLM). Electrophysiological characterization shows that the majority of identified PeH-RVLM neurons, including a subpopulation of orexin neurons, are activated in response to hypoglycemia or glucoprivation. Furthermore, the excitatory input from the PeH is mediated by orexin type 2 receptors in the RVLM. These results suggest that activation of orexin PeH-RVLM neurons and orexin type 2 receptors in the RVLM facilitates epinephrine release by increasing sympathetic drive to adrenal chromaffin cells during hypoglycemia.en_US
dc.subjectAdrenal Glandsen_US
dc.subjectMedulla Oblongataen_US
dc.subjectOrexin Receptorsen_US
dc.titleActivation of medulla-projecting perifornical neurons modulates the adrenal sympathetic response to hypoglycemia: involvement of orexin type 2 (OX2-R) receptorsen_US
dc.typeJournal Articleen_US
dc.identifier.affiliationClinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationCardiovascular Medicine, Human Physiology and Centre for Neuroscience, School of Medicine, Flinders University, Bedford Park, South Australia, Australiaen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article- Pharmacology and Therapeutics- (University of Melbourne)-
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