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https://ahro.austin.org.au/austinjspui/handle/1/12938| Title: | Impairment of inhibitory cardiopulmonary vagal reflexes in spontaneously hypertensive rats. | Austin Authors: | Verberne, Anthony J M ;Young, N A;Louis, William J | Affiliation: | University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Australia | Issue Date: | 1-Jun-1988 | Publication information: | Journal of the Autonomic Nervous System; 23(1): 63-8 | Abstract: | The activity of cardiopulmonary reflexes elicited by 5-hydroxytryptamine (5-HT) and phenyldiguanide (PDG) has been examined in anaesthetised 5- and 12-week-old spontaneously hypertensive (SHR) rats. Intravenous injections of 5-HT or PDG elicited dose-dependent bradycardic and hypotensive responses. In the 5-week-old SHR rats the bradycardic and hypotensive responses to 5-HT were smaller than those measured in WKY rats. At 12 weeks, the SHR rats were less sensitive to the bradycardic actions of 5-HT, as well as PDG, although the reduction in cardiopulmonary reflex sensitivity was less pronounced than that observed in the 5-week-old SHR rats. These findings suggest that cardiopulmonary reflexes are impaired in the SHR rat although some amelioration of this phenomenon may occur as hypertension develops. | Gov't Doc #: | 3171087 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12938 | Journal: | Journal of the autonomic nervous system | URL: | https://pubmed.ncbi.nlm.nih.gov/3171087 | Type: | Journal Article | Subjects: | Animals Blood Pressure.drug effects Diastole Heart.physiopathology Heart Rate.drug effects Lung.physiopathology Male Rats Rats, Inbred SHR.physiology Rats, Inbred Strains.physiology Rats, Inbred WKY.physiology Reflex.physiology Rest Serotonin.pharmacology Vagus Nerve.physiology |
| Appears in Collections: | Journal articles |
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