Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12938
Title: Impairment of inhibitory cardiopulmonary vagal reflexes in spontaneously hypertensive rats.
Austin Authors: Verberne, Anthony J M ;Young, N A;Louis, William J 
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Australia
Issue Date: 1-Jun-1988
Publication information: Journal of the Autonomic Nervous System; 23(1): 63-8
Abstract: The activity of cardiopulmonary reflexes elicited by 5-hydroxytryptamine (5-HT) and phenyldiguanide (PDG) has been examined in anaesthetised 5- and 12-week-old spontaneously hypertensive (SHR) rats. Intravenous injections of 5-HT or PDG elicited dose-dependent bradycardic and hypotensive responses. In the 5-week-old SHR rats the bradycardic and hypotensive responses to 5-HT were smaller than those measured in WKY rats. At 12 weeks, the SHR rats were less sensitive to the bradycardic actions of 5-HT, as well as PDG, although the reduction in cardiopulmonary reflex sensitivity was less pronounced than that observed in the 5-week-old SHR rats. These findings suggest that cardiopulmonary reflexes are impaired in the SHR rat although some amelioration of this phenomenon may occur as hypertension develops.
Gov't Doc #: 3171087
URI: https://ahro.austin.org.au/austinjspui/handle/1/12938
Journal: Journal of the autonomic nervous system
URL: https://pubmed.ncbi.nlm.nih.gov/3171087
Type: Journal Article
Subjects: Animals
Blood Pressure.drug effects
Diastole
Heart.physiopathology
Heart Rate.drug effects
Lung.physiopathology
Male
Rats
Rats, Inbred SHR.physiology
Rats, Inbred Strains.physiology
Rats, Inbred WKY.physiology
Reflex.physiology
Rest
Serotonin.pharmacology
Vagus Nerve.physiology
Appears in Collections:Journal articles

Show full item record

Page view(s)

26
checked on Nov 3, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.