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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12938
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dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorYoung, N Aen
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T02:42:07Z
dc.date.available2015-05-16T02:42:07Z
dc.date.issued1988-06-01en
dc.identifier.citationJournal of the Autonomic Nervous System; 23(1): 63-8en
dc.identifier.govdoc3171087en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12938en
dc.description.abstractThe activity of cardiopulmonary reflexes elicited by 5-hydroxytryptamine (5-HT) and phenyldiguanide (PDG) has been examined in anaesthetised 5- and 12-week-old spontaneously hypertensive (SHR) rats. Intravenous injections of 5-HT or PDG elicited dose-dependent bradycardic and hypotensive responses. In the 5-week-old SHR rats the bradycardic and hypotensive responses to 5-HT were smaller than those measured in WKY rats. At 12 weeks, the SHR rats were less sensitive to the bradycardic actions of 5-HT, as well as PDG, although the reduction in cardiopulmonary reflex sensitivity was less pronounced than that observed in the 5-week-old SHR rats. These findings suggest that cardiopulmonary reflexes are impaired in the SHR rat although some amelioration of this phenomenon may occur as hypertension develops.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherDiastoleen
dc.subject.otherHeart.physiopathologyen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherLung.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHR.physiologyen
dc.subject.otherRats, Inbred Strains.physiologyen
dc.subject.otherRats, Inbred WKY.physiologyen
dc.subject.otherReflex.physiologyen
dc.subject.otherResten
dc.subject.otherSerotonin.pharmacologyen
dc.subject.otherVagus Nerve.physiologyen
dc.titleImpairment of inhibitory cardiopulmonary vagal reflexes in spontaneously hypertensive rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of the autonomic nervous systemen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Australiaen
dc.description.pages63-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3171087en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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