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https://ahro.austin.org.au/austinjspui/handle/1/12847| Title: | The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat. | Austin Authors: | Verberne, Anthony J M ;Costa, M;Lewis, S J;Louis, William J ;Beart, P M | Affiliation: | University of Melbourne, Department of Medicine, Austin, Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Aug-1987 | Publication information: | Neuropharmacology; 26(8): 1243-6 | Abstract: | The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5-16 microgram/kg) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg/kg, i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc. | Gov't Doc #: | 2821444 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12847 | Journal: | Neuropharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/2821444 | Type: | Journal Article | Subjects: | Anesthesia Animals Blood Pressure.drug effects Cardiovascular Physiological Phenomena Dibenzocycloheptenes.pharmacology Dizocilpine Maleate Heart Rate.drug effects Male Rats Rats, Inbred WKY Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter.metabolism Reflex.drug effects Sensory Receptor Cells.drug effects Serotonin.pharmacology Urethane |
| Appears in Collections: | Journal articles |
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