Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12847
Title: The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat.
Austin Authors: Verberne, Anthony J M ;Costa, M;Lewis, S J;Louis, William J ;Beart, P M
Affiliation: University of Melbourne, Department of Medicine, Austin, Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-1987
Publication information: Neuropharmacology; 26(8): 1243-6
Abstract: The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5-16 microgram/kg) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg/kg, i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc.
Gov't Doc #: 2821444
URI: https://ahro.austin.org.au/austinjspui/handle/1/12847
Journal: Neuropharmacology
URL: https://pubmed.ncbi.nlm.nih.gov/2821444
Type: Journal Article
Subjects: Anesthesia
Animals
Blood Pressure.drug effects
Cardiovascular Physiological Phenomena
Dibenzocycloheptenes.pharmacology
Dizocilpine Maleate
Heart Rate.drug effects
Male
Rats
Rats, Inbred WKY
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter.metabolism
Reflex.drug effects
Sensory Receptor Cells.drug effects
Serotonin.pharmacology
Urethane
Appears in Collections:Journal articles

Show full item record

Page view(s)

20
checked on Oct 11, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.