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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12847
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dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorCosta, Men
dc.contributor.authorLewis, S Jen
dc.contributor.authorLouis, William Jen
dc.contributor.authorBeart, P Men
dc.date.accessioned2015-05-16T02:35:39Z
dc.date.available2015-05-16T02:35:39Z
dc.date.issued1987-08-01en
dc.identifier.citationNeuropharmacology; 26(8): 1243-6en
dc.identifier.govdoc2821444en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12847en
dc.description.abstractThe effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5-16 microgram/kg) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg/kg, i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc.en
dc.language.isoenen
dc.subject.otherAnesthesiaen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCardiovascular Physiological Phenomenaen
dc.subject.otherDibenzocycloheptenes.pharmacologyen
dc.subject.otherDizocilpine Maleateen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherMaleen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReceptors, N-Methyl-D-Aspartateen
dc.subject.otherReceptors, Neurotransmitter.metabolismen
dc.subject.otherReflex.drug effectsen
dc.subject.otherSensory Receptor Cells.drug effectsen
dc.subject.otherSerotonin.pharmacologyen
dc.subject.otherUrethaneen
dc.titleThe N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuropharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin, Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages1243-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2821444en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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