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Title: Charting cognitive and volumetric trajectories after stroke: protocol for the Cognition And Neocortical Volume After Stroke (CANVAS) study.
Austin Authors: Brodtmann, Amy ;Werden, Emilio ;Pardoe, Heath R;Li, Qi;Jackson, Graeme D;Donnan, Geoffrey A ;Cowie, Tiffany;Bradshaw, Jennifer;Darby, David G;Cumming, Toby B 
Affiliation: Eastern Clinical Research Unit, Monash University, Box Hill Hospital, Melbourne, Victoria, Australia
Austin Health, Heidelberg, Melbourne, Victoria, Australia
The Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 3-Jun-2014
Publication information: International Journal of Stroke 2014; 9(6): 824-8
Abstract: Globally, stroke and dementia are leading causes of disability and mortality. More than one third of stroke patients will develop dementia, but mechanisms are unclear.The study aims to establish whether brain volume change is associated with poststroke dementia, and to elucidate potential causal mechanisms, including genetic markers, amyloid deposition and vascular risk factors. An understanding of whether - and in whom - stroke is neurodegenerative is critical for the strategic use of potential disease-modifying therapies.That stroke patients will exhibit greater brain volume loss than comparable cohorts of stroke-free controls; and that those who develop dementia will exhibit greater brain volume loss than those who do not.Advanced brain imaging techniques are used to longitudinally measure brain volume and cortical thickness in 135 stroke patients. Concurrent neuropsychological testing will correlate clinical profile with these measures.Primary imaging end-point is brain volume change between three-months and three-years poststroke; primary clinical outcome is the presence of dementia at three-years.We will examine the correlations with the following variables: dementia subtype; physical activity levels; behavioral dysfunction as measured by patient and caregiver-reported scales; structural and functional brain connectivity disruption; apolipoprotein E; and specific neuropsychological test scores.Magnetic resonance imaging markers of structural brain aging and performance on neuropsychological tests are powerful predictors of dementia. We need to understand the trajectory of regional brain volume change and cognitive decline in patients after stroke. This will allow future risk stratification for prognostic counseling, service planning, and early therapeutic intervention.
Gov't Doc #: 24894387
DOI: 10.1111/ijs.12301
Type: Journal Article
Subjects: MRI
cortical thickness
Apolipoproteins E.metabolism
Brain Ischemia.complications.diagnosis.pathology.psychology
Clinical Protocols
Cohort Studies
Longitudinal Studies
Magnetic Resonance Imaging
Motor Activity
Neuropsychological Tests
Organ Size
Patient Selection
Sample Size
Time Factors
Appears in Collections:Journal articles

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