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Title: Vasoactive role for angiotensin II type 2 receptors in human radial artery.
Austin Authors: Zulli, Anthony;Hare, David L ;Buxton, Brian F ;Widdop, Robert E
Affiliation: Departments of Cardiac Surgery, Austin Health, Heidelberg, Victoria, Australia
Department of Pharmacology, Monash University, Australia
College of Health and Biomedicine, Victoria University, St Albans, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 3-Jan-2014
Publication information: International Journal of Immunopathology and Pharmacology; 27(1): 79-85
Abstract: Angotensin II type 2 receptors are believed to counter the effects of the angiotensin type 1 receptors and there is no data relating to the co-localisation of either receptor in human diseased arteries. We sought to determine whether AT2R counter the effects of AT1R and immunolocalise both receptors to cells in human diseased arteries. Human radial arteries (RA, n=11) were placed in organ bath chambers and preincubated with the AT2R antagonist PD123319 for twenty minutes before an angiotensin II dose response curve. Immunohistochemistry was performed to identify receptors and pathology was quantified by image analysis software. We observed both receptors in human arteries. Angiogenic blood vessels within occluded arteries expressed both receptors. PD123319 impaired angiotensin II mediated vasoconstriction by 20 percent (n=5, p less than 0.05), however in other arteries, PD123319 exacerbated angiotensin II-mediated vasoconstriction by 60 percent (n=6, p less than 0.01), respectively. We conclude that inhibition of AT2R can enhance or reduce angiotensin II-mediated vasoconstriction. These data indicate that the role of AT2R in human diseased arteries is divergent although the AT2R-mediated vasorelaxation prevails.
Gov't Doc #: 24674681
ORCID: 0000-0001-9554-6556
PubMed URL: 24674681
Type: Journal Article
Subjects: Angiotensin II Type 2 Receptor Blockers.pharmacology
In Vitro Techniques
Radial Artery.drug effects.metabolism.pathology
Receptor, Angiotensin, Type 1.metabolism
Receptor, Angiotensin, Type 2.metabolism
Vasoconstriction.drug effects.physiology
Vasodilation.drug effects.physiology
Appears in Collections:Journal articles

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