Please use this identifier to cite or link to this item:
Title: Neural pathways that control the glucose counterregulatory response.
Austin Authors: Verberne, Anthony J M ;Sabetghadam, Azadeh;Korim, Willian S
Affiliation: Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Health Heidelberg, The University of Melbourne Melbourne, Victoria, Australia
Issue Date: 26-Feb-2014
Publication information: Frontiers in Neuroscience 2014; 8(): 38
Abstract: Glucose is an essential metabolic substrate for all bodily tissues. The brain depends particularly on a constant supply of glucose to satisfy its energy demands. Fortunately, a complex physiological system has evolved to keep blood glucose at a constant level. The consequences of poor glucose homeostasis are well-known: hyperglycemia associated with uncontrolled diabetes can lead to cardiovascular disease, neuropathy and nephropathy, while hypoglycemia can lead to convulsions, loss of consciousness, coma, and even death. The glucose counterregulatory response involves detection of declining plasma glucose levels and secretion of several hormones including glucagon, adrenaline, cortisol, and growth hormone (GH) to orchestrate the recovery from hypoglycemia. Low blood glucose leads to a low brain glucose level that is detected by glucose-sensing neurons located in several brain regions such as the ventromedial hypothalamus, the perifornical region of the lateral hypothalamus, the arcuate nucleus (ARC), and in several hindbrain regions. This review will describe the importance of the glucose counterregulatory system and what is known of the neurocircuitry that underpins it.
Gov't Doc #: 24616659
DOI: 10.3389/fnins.2014.00038
Type: Journal Article
Subjects: adrenaline
glucose sensing
perifornical hypothalamus
rostral ventrolateral medulla
ventromedial hypothalamus
Appears in Collections:Journal articles

Show full item record

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.