Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12120
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dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorSabetghadam, Azadehen
dc.contributor.authorKorim, Willian Sen
dc.date.accessioned2015-05-16T01:46:09Z
dc.date.available2015-05-16T01:46:09Z
dc.date.issued2014-02-26en
dc.identifier.citationFrontiers in Neuroscience 2014; 8(): 38en
dc.identifier.govdoc24616659en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12120en
dc.description.abstractGlucose is an essential metabolic substrate for all bodily tissues. The brain depends particularly on a constant supply of glucose to satisfy its energy demands. Fortunately, a complex physiological system has evolved to keep blood glucose at a constant level. The consequences of poor glucose homeostasis are well-known: hyperglycemia associated with uncontrolled diabetes can lead to cardiovascular disease, neuropathy and nephropathy, while hypoglycemia can lead to convulsions, loss of consciousness, coma, and even death. The glucose counterregulatory response involves detection of declining plasma glucose levels and secretion of several hormones including glucagon, adrenaline, cortisol, and growth hormone (GH) to orchestrate the recovery from hypoglycemia. Low blood glucose leads to a low brain glucose level that is detected by glucose-sensing neurons located in several brain regions such as the ventromedial hypothalamus, the perifornical region of the lateral hypothalamus, the arcuate nucleus (ARC), and in several hindbrain regions. This review will describe the importance of the glucose counterregulatory system and what is known of the neurocircuitry that underpins it.en
dc.language.isoenen
dc.subject.otheradrenalineen
dc.subject.othercounterregulationen
dc.subject.otherglucagonen
dc.subject.otherglucose sensingen
dc.subject.otherhypoglycemiaen
dc.subject.otherperifornical hypothalamusen
dc.subject.otherrostral ventrolateral medullaen
dc.subject.otherventromedial hypothalamusen
dc.titleNeural pathways that control the glucose counterregulatory response.en
dc.typeJournal Articleen
dc.identifier.journaltitleFrontiers in neuroscienceen
dc.identifier.affiliationClinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Health Heidelberg, The University of Melbourne Melbourne, Victoria, Australiaen
dc.identifier.doi10.3389/fnins.2014.00038en
dc.description.pages38en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24616659en
dc.type.austinJournal Articleen
local.name.researcherVerberne, Anthony J M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
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