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Title: Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats.
Austin Authors: Verberne, Anthony J M ;Widdop, Robert E;Maccarrone, C;Jarrott, B;Beart, P M;Louis, William J 
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 13-Jul-1990
Publication information: Neuroscience Letters; 114(3): 309-15
Abstract: In the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol in 10 microliters) caused a dramatic reduction in mean arterial pressure (MAP) and heart rate (HR) that persisted for 2-3 h, and also resulted in extensor paralysis of the hindlimbs. The time courses of fall in MAP and HR and hindlimb paralysis were similar. Baroreceptor-HR reflex activity was also markedly impaired after KYN, suggesting functional diminution of sympathetic outflow at the level of the spinal cord after blockade of EAA receptors by KYN. Xanthurenate, a metabolite of KYN without EAA antagonistic properties, produced negligible effects at the same dose of KYN. While these findings do not identify the putative EAA pathway, they do provide the first demonstration that this system is tonically active in conscious rats.
Gov't Doc #: 2402340
Journal: Neuroscience letters
Type: Journal Article
Subjects: Animals
Blood Pressure.drug effects
Heart Rate.drug effects
Kynurenic Acid.pharmacology
Reflex.drug effects
Appears in Collections:Journal articles

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