Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11869
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dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorWiddop, Robert Een
dc.contributor.authorMaccarrone, Cen
dc.contributor.authorJarrott, Ben
dc.contributor.authorBeart, P Men
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T01:29:58Z
dc.date.available2015-05-16T01:29:58Z
dc.date.issued1990-07-13en
dc.identifier.citationNeuroscience Letters; 114(3): 309-15en
dc.identifier.govdoc2402340en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11869en
dc.description.abstractIn the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol in 10 microliters) caused a dramatic reduction in mean arterial pressure (MAP) and heart rate (HR) that persisted for 2-3 h, and also resulted in extensor paralysis of the hindlimbs. The time courses of fall in MAP and HR and hindlimb paralysis were similar. Baroreceptor-HR reflex activity was also markedly impaired after KYN, suggesting functional diminution of sympathetic outflow at the level of the spinal cord after blockade of EAA receptors by KYN. Xanthurenate, a metabolite of KYN without EAA antagonistic properties, produced negligible effects at the same dose of KYN. While these findings do not identify the putative EAA pathway, they do provide the first demonstration that this system is tonically active in conscious rats.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherFemaleen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherKynurenic Acid.pharmacologyen
dc.subject.otherMaleen
dc.subject.otherPressoreceptors.physiologyen
dc.subject.otherRatsen
dc.subject.otherReflex.drug effectsen
dc.titleIntrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroscience lettersen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages309-15en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2402340en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptClinical Pharmacology and Therapeutics-
Appears in Collections:Journal articles
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