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Title: Post-liver transplant leptin results in resolution of severe recurrence of lipodystrophy-associated nonalcoholic steatohepatitis.
Austin Authors: Casey, S P;Lokan, Julie ;Testro, Adam G ;Farquharson, Shawna ;Connelly, A;Proietto, Joseph ;Angus, Peter W 
Affiliation: Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 5-Sep-2013
Publication information: American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013; 13(11): 3031-4
Abstract: We describe the first case of a patient undergoing orthoptic liver transplantation for acquired generalized lipodystrophy-related nonalcoholic steatohepatitis who developed severe recurrence of nonalcoholic fatty liver disease in the first few months posttransplant but responded rapidly to the administration of exogenous leptin. The beneficial effects of therapy were supported by histology along with magnetic resonance spectroscopy studies, which demonstrated that leptin therapy greatly reduced fat deposition in the liver. Leptin therapy may have a role to play in preventing patients with lipodystrophy developing end-stage liver disease or in rescuing such patients who develop disease recurrence postliver transplantation.
Gov't Doc #: 24007548
DOI: 10.1111/ajt.12436
Type: Journal Article
Subjects: Leptin
liver transplantation
nonalcoholic steatohepatitis
Liver Transplantation.adverse effects
Magnetic Resonance Spectroscopy
Non-alcoholic Fatty Liver Disease
Postoperative Complications.prevention & control
Secondary Prevention
Treatment Outcome
Appears in Collections:Journal articles

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