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|Title:||Low testosterone levels as an independent predictor of mortality in men with chronic liver disease.||Austin Authors:||Grossmann, Mathis ;Hoermann, Rudolf;Gani, Linsey;Chan, Irene;Cheung, Ada S ;Gow, Paul J ;Li, Angela;Zajac, Jeffrey D ;Angus, Peter W||Affiliation:||Endocrine Unit, Department of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia||Issue Date:||1-Aug-2012||Publication information:||Clinical Endocrinology; 77(2): 323-8||Abstract:||To examine the prevalence and prognostic implications of low serum testosterone levels in men with chronic liver disease.We conducted an observational study at a tertiary referral centre.Baseline serum testosterone was measured in 171 men presenting to the Victorian Liver Transplant Unit for liver transplant evaluation. Patients were followed up to liver transplant or death.Sixty-one per cent of men had a low total testosterone level (TT, <10 nm), and 90% of men had a low calculated free testosterone level (cFT, <230 pm). During the available observation time (median 8 months, interquartile range 4-14 months), 56 men (33%) died and 63 (37%) received a liver transplant. Fifty-two (30%) survived without a transplant. Median time to death was 8 months (range 2-13) and to liver transplant was 8 months (4-14). Baseline low TT and cFT levels both (P < 0·0001) predicted mortality. Moreover, in a Cox proportional hazard model, both low total (P = 0·02) and free testosterone (P = 0·007) levels remained predictive of death independently of established prognostic factors, such as the model for end-stage liver disease (MELD) score and serum sodium levels. A decrease in TT by 1 nm and in cFT by 10 pm was associated with an 8% increase in mortality.Low testosterone levels are common in men with severe liver disease and predict mortality independent of MELD, the standard score used to prioritize the allocation of liver transplants.||Gov't Doc #:||22280063||URI:||http://ahro.austin.org.au/austinjspui/handle/1/11427||DOI:||10.1111/j.1365-2265.2012.04347.x||URL:||https://pubmed.ncbi.nlm.nih.gov/22280063||Type:||Journal Article||Subjects:||Chronic Disease.mortality
|Appears in Collections:||Journal articles|
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