Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11427
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dc.contributor.authorGrossmann, Mathis-
dc.contributor.authorHoermann, Rudolf-
dc.contributor.authorGani, Linsey-
dc.contributor.authorChan, Irene-
dc.contributor.authorCheung, Ada S-
dc.contributor.authorGow, Paul J-
dc.contributor.authorLi, Angela-
dc.contributor.authorZajac, Jeffrey D-
dc.contributor.authorAngus, Peter W-
dc.date.accessioned2015-05-16T01:02:07Z
dc.date.available2015-05-16T01:02:07Z
dc.date.issued2012-08-01-
dc.identifier.citationClinical Endocrinology; 77(2): 323-8en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11427en
dc.description.abstractTo examine the prevalence and prognostic implications of low serum testosterone levels in men with chronic liver disease.We conducted an observational study at a tertiary referral centre.Baseline serum testosterone was measured in 171 men presenting to the Victorian Liver Transplant Unit for liver transplant evaluation. Patients were followed up to liver transplant or death.Sixty-one per cent of men had a low total testosterone level (TT, <10 nm), and 90% of men had a low calculated free testosterone level (cFT, <230 pm). During the available observation time (median 8 months, interquartile range 4-14 months), 56 men (33%) died and 63 (37%) received a liver transplant. Fifty-two (30%) survived without a transplant. Median time to death was 8 months (range 2-13) and to liver transplant was 8 months (4-14). Baseline low TT and cFT levels both (P < 0·0001) predicted mortality. Moreover, in a Cox proportional hazard model, both low total (P = 0·02) and free testosterone (P = 0·007) levels remained predictive of death independently of established prognostic factors, such as the model for end-stage liver disease (MELD) score and serum sodium levels. A decrease in TT by 1 nm and in cFT by 10 pm was associated with an 8% increase in mortality.Low testosterone levels are common in men with severe liver disease and predict mortality independent of MELD, the standard score used to prioritize the allocation of liver transplants.en_US
dc.language.isoenen
dc.subject.otherChronic Disease.mortalityen
dc.subject.otherHumansen
dc.subject.otherLiver Diseases.blood.mortalityen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherTestosterone.blooden
dc.titleLow testosterone levels as an independent predictor of mortality in men with chronic liver disease.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical Endocrinologyen_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.affiliationGeneral Medicineen_US
dc.identifier.doi10.1111/j.1365-2265.2012.04347.xen_US
dc.description.pages323-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22280063en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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