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Title: Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease.
Austin Authors: Yates, Paul A ;Sirisriro, R;Villemagne, Victor L ;Farquharson, Shawna ;Masters, Colin L ;Rowe, Christopher C 
Institutional Author: AIBL Research Group
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia
Issue Date: 22-Jun-2011
Publication information: Neurology 2011; 77(1): 48-54
Abstract: Incidental cerebral microhemorrhage (MH) is frequently found in older individuals scanned with susceptibility-weighted MRI (SWI) or gradient-recalled echo MRI. MH have been linked with β-amyloid (Aβ) deposition using (11)C-Pittsburgh compound B (PiB) PET in Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA). We hypothesized that Aβ deposition in asymptomatic elderly individuals is associated with lobar MH (LMH).This was a cross-sectional study of 84 elderly healthy controls (HC), 28 subjects with mild cognitive impairment (MCI), and 26 subjects with probable AD who underwent 3-T SWI and (11)C-PiB PET. (11)C-PiB cortical binding was quantified normalized to cerebellar cortex (standardized uptake value ratio [SUVR]) and scans classified as positive (PiB+) or negative (PiB-) by visual inspection. MH were manually counted and categorized by region and as lobar or nonlobar.LMH were present in 30.8% of AD, 35.7% of MCI, and 19.1% of HC. The prevalence of LMH among PiB+ subjects was similar, regardless of clinical classification (AD 30.8%, MCI 38.9%, HC 41.4%, p > 0.7). HC with LMH had significantly higher mean neocortical SUVR (1.7 ± 0.5) than HC without LMH (1.3 ± 0.3, p ± 0.01). In HC, there was a positive correlation between number of LMH and SUVR, and between LMH and age. In HC, PiB+ (odds ratio [OR] 7.3, 95% confidence interval [CI] 1.6-33.7, p = 0.01) and age (OR 1.2, 95% CI 1.03-1.3, p = 0.02) both independently predicted the occurrence of LMH using logistic regression.Asymptomatic Aβ deposition in older adults is strongly associated with LMH.
DOI: 10.1212/WNL.0b013e318221ad36
Journal: Neurology
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Alzheimer Disease.genetics.pathology.radionuclide imaging
Amyloid beta-Peptides.metabolism
Apolipoprotein E4.genetics
Benzothiazoles.diagnostic use
Brain.metabolism.radionuclide imaging
Brain Mapping
Carbon Radioisotopes.diagnostic use
Cerebral Hemorrhage.etiology
Cognition Disorders.genetics.pathology.radionuclide imaging
Logistic Models
Magnetic Resonance Imaging.methods
Nerve Fibers, Myelinated.pathology.radionuclide imaging
Positron-Emission Tomography.methods
Psychiatric Status Rating Scales
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