Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11291
Title: Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease.
Austin Authors: Yates, Paul A ;Sirisriro, R;Villemagne, Victor L ;Farquharson, Shawna ;Masters, Colin L ;Rowe, Christopher C 
Institutional Author: AIBL Research Group
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia
Issue Date: 22-Jun-2011
Publication information: Neurology 2011; 77(1): 48-54
Abstract: Incidental cerebral microhemorrhage (MH) is frequently found in older individuals scanned with susceptibility-weighted MRI (SWI) or gradient-recalled echo MRI. MH have been linked with β-amyloid (Aβ) deposition using (11)C-Pittsburgh compound B (PiB) PET in Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA). We hypothesized that Aβ deposition in asymptomatic elderly individuals is associated with lobar MH (LMH).This was a cross-sectional study of 84 elderly healthy controls (HC), 28 subjects with mild cognitive impairment (MCI), and 26 subjects with probable AD who underwent 3-T SWI and (11)C-PiB PET. (11)C-PiB cortical binding was quantified normalized to cerebellar cortex (standardized uptake value ratio [SUVR]) and scans classified as positive (PiB+) or negative (PiB-) by visual inspection. MH were manually counted and categorized by region and as lobar or nonlobar.LMH were present in 30.8% of AD, 35.7% of MCI, and 19.1% of HC. The prevalence of LMH among PiB+ subjects was similar, regardless of clinical classification (AD 30.8%, MCI 38.9%, HC 41.4%, p > 0.7). HC with LMH had significantly higher mean neocortical SUVR (1.7 ± 0.5) than HC without LMH (1.3 ± 0.3, p ± 0.01). In HC, there was a positive correlation between number of LMH and SUVR, and between LMH and age. In HC, PiB+ (odds ratio [OR] 7.3, 95% confidence interval [CI] 1.6-33.7, p = 0.01) and age (OR 1.2, 95% CI 1.03-1.3, p = 0.02) both independently predicted the occurrence of LMH using logistic regression.Asymptomatic Aβ deposition in older adults is strongly associated with LMH.
URI: https://ahro.austin.org.au/austinjspui/handle/1/11291
DOI: 10.1212/WNL.0b013e318221ad36
Journal: Neurology
URL: https://pubmed.ncbi.nlm.nih.gov/21700585
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Aging.pathology
Alzheimer Disease.genetics.pathology.radionuclide imaging
Amyloid beta-Peptides.metabolism
Apolipoprotein E4.genetics
Benzothiazoles.diagnostic use
Brain.metabolism.radionuclide imaging
Brain Mapping
Carbon Radioisotopes.diagnostic use
Cerebral Hemorrhage.etiology
Cognition Disorders.genetics.pathology.radionuclide imaging
Female
Humans
Logistic Models
Magnetic Resonance Imaging.methods
Male
Nerve Fibers, Myelinated.pathology.radionuclide imaging
Positron-Emission Tomography.methods
Psychiatric Status Rating Scales
Appears in Collections:Journal articles

Show full item record

Page view(s)

54
checked on Mar 27, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.